厄贝沙坦联合美托洛尔对急诊重症心力衰竭患者左心射血分数、B型脑钠肽、心功能分级的影响

Irbesartan combined with metoprolol on left ventricular ejection fraction in patients with severe heart failure in emergency, b-type natriuretic peptide and cardiac function classification of impact

目的探究厄贝沙坦联合美托洛尔对急诊重症心力衰竭患者左心射血分数、B型脑钠肽、心功能分级的影响。方法选取2015年12月~2016年12月本院急诊科收治的70例重症心力衰竭患者作为观察对象,采用数字分组法将选取的患者分为观察组和对照组,每组35例。观察组患者采用厄贝沙坦联合美托洛尔治疗,对照组患者采用常规疗法。分别观察两种治疗方法下患者的左心射血分数、B型脑钠肽、心功能分级的差异。结果治疗前,两组患者的左心射血分数、B型脑钠肽、心功能分级比较差异无统计学意义;治疗后,两组患者的病情均得到改善,但观察组患者的回复情况更佳,观察组患者的左心射血分数、B型脑钠肽、心功能分级显著优于对照组,二者之间各项指标比较差异具有统计学意义(P<0.05)。同时,观察组出现头晕、头痛等不良反应的患者有3例,占8.6%,对照组出现头晕、头痛等不良反应的患者有11例,占31.4%,两组间的不良反应发生率进行比较得出的差异具有统计学意义(c2=5.7143,P<0.05)。结论厄贝沙坦联合美托洛尔对急诊重症心力衰竭患者治疗的效果较好,有效改善了患者的左心射血分数、B型脑钠肽、心功能分级,并且患者出现不良反应的情况也较少,治疗的安全性和可行性也较高,值得在临床进行推广。

Objective To explore the urban bei sha Tanzania joint metoprolol for emergency and severe cases of left heart ejection fraction in patients with heart failure,b-type brain natriuretic peptide,the effect of cardiac function classification.Methods70patients with severe heart failure in the emergency department were in from December2015to December2016in our hospital as research object,.Adopting digital grouping will select patients were divided into observation and control group,35patients in each group.The observation group was treated with irbesartan combined with metoprolol and the control group was treated with conventional therapy.Under two treatment methods were observed in patients with left heart ejection fraction,b-type brain natriuretic peptide,the differences between the cardiac function classification.Results Before treatment,two groups of patients with left heart ejection fraction,b-type brain natriuretic peptide and heart function classification has no obvious difference,after treatment,the condition of two groups of patients were improved,but the observation group of patients with better reply situation,in patients with left heart ejection fraction,b-type brain natriuretic peptide and heart function classification is significantly better than that of control group,each index to compare the results between statistically significant(P<0.05).At the same time,in the observation group of patients with dizziness,headaches and other adverse reactions in3cases,accounted for8.6%,the control group,the adverse reactions such as dizziness,headache in11patients(31.4%),compared the incidence of adverse reactions between the two groups were significant difference of(c2=5.7143,P<0.05).Conclusion Irbesartan joint metoprolol for emergency patients with severe heart failure treatment effect is good,effectively improve the patient's left heart ejection fraction,b-type brain natriuretic peptide and grade of cardiac function,and adverse reactions of patients is less,the safety and feasibility of treatment also is higher,is worth popularization in clinical.