帕金森病冻结步态患者的临床特征分析

Analysis of clinical characteristics of patients with parkinson disease freezing gait

目的:探讨帕金森病冻结步态患者的临床特征。方法:收治帕金森病患者78例,分为帕金森病冻结步态组和不冻结步态组各39例。采用H-Y分级和帕金森病评分量表评价患者临床特征,采用汉密尔顿抑郁量表(HAMD)评估患者非运动症状。结果:帕金森病冻结步态组患者的H-Y分级明显高于不冻结步态组,尤其3期以上的患者(P<0.05);帕金森病冻结步态组患者的帕金森量表评分(UPDRS)也高于不冻结步态组(P<0.05);帕金森病冻结步态组1例未发生抑郁,不冻结步态组9例未发生抑郁(P<0.05)。结论:帕金森病患者伴随冻结步态是其常见的临床特征,出现冻结步态一般与患者精神状态抑郁、病情发展等有关。

Objective:To explore the clinical characteristics of patients with parkinson disease freezing gait.Methods:78patients with parkinson disease were selected.They were divided into the parkinson disease freezing gait group and the non frozen gait group with39cases in each.The clinical features of patients were evaluated by H-Y classification and parkinson disease rating scale,and the non motor symptoms of patients were assessed by hamiltons depression scale(HAMD).Results:The H-Y classification of the parkinson disease freezing gait group was significantly higher than that of the non frozen gait group,especially in patients with stage3or above(P<0.05).The parkinson rating scale(UPDRS)of the parkinson disease freezing gait group was significantly higher than that of the non frozen gait group(P<0.05).1case had no depression in the parkinson disease freezing gait group,9cases had no depression in the non frozen gait group(P<0.05).Conclusion:It is a common clinical feature of patients with parkinson disease to accompany with freezing gait.The appearance of freezing gait is generally related to the mental state depression,illness development of patients.