动物颈脊髓压迫模型的研究进展

Advances in the animal model of cervical cord compression

脊髓型颈椎病是导致成人脊髓功能障碍最常见的疾病。矛盾的是,对于脊髓型颈椎病患者脊髓神经组织进展性功能丧失的病理生物学机制却不甚清楚。经过20世纪本领域科学家的大量研究证实,脊髓压迫模型不论是在研究治疗脊髓型颈椎病功效方面还是在探索其发病机制方面都是重要的。脊髓压迫的临床前研究需要一个可分级、可量化、可重复的动物模型。笔者从动物的选择、动物模型的制作和脊髓损伤神经功能评估三个方面分别来阐述动物脊髓压迫模型的建立。

Cervical spondylotic myelopathy is the most common cause of spinal cord dysfunction in adults.Paradoxically,the pathobiological mechanisms associated with the progressive loss of neural tissue in the spinal cord of cervical spondylotic myelopathy patients is not clearly understood.The results of many studies in this field in20th century have shown that spinal cord compression models are indispensible not only in investigating the efficacy of therapeutic interventions but also in gaining a better understanding into the molecular pathways involved.Preclinical studies on spinal cord compression require a reproducible,gradable,and quantifiable animal model.In this paper,the author elaborates on the establishment of an animal model of spinal cord compression from the aspects of the selection of animals,the production of animal models an d neurological assessment in spinal cord injury.