铜仁市人民医院近5年胆汁微生物学变化及药敏分析

Analysis on the Changes of Bile Microbiology and Drug Sensitivity in Tongren people's Hospital in Recent 5 Years

目的为了建立有效的经验性用药方案,为医师提供合理应用抗菌药物的依据,从而有效地提高其治疗效果,降低病死率。方法分析铜仁市人民医院2011年11月~2016年10月间146例胆汁培养阳性细菌分布及药敏。结果 146株细菌培养阳性率前三种分别是:大肠埃希菌、克雷伯菌属、肠球菌属。革兰阴性杆菌中对常用的抗菌药物敏感率较高的是阿米卡星、哌拉西林/他唑巴坦、头孢替坦;革兰阳性球菌中对常用的青霉素类及喹若酮抗菌药物均较敏感。结论本组胆汁中病因微生物变化仍是以大肠埃希菌为主,建议胆道细菌感染患者推荐选用阿米卡星、哌拉西林/他唑巴坦、头孢替坦。

Objective In order to establish an effective program of empirical drug use, to provide reasonable basis for the rational use of antimicrobial agents for general physician,so as to effectively improve the treatment effect,reduce mortality. Method Distribution and drug sensitivity of 146 cases of bile culture positive bacteria from November 2011 to October 2016 were analyzed. Results The postive rates of 146 strains bacteria culture were: Escherichia coli, Klebsiella and Enterococcus, respectively. The susceptibility rates of gram negative bacilli to the commonly used antibiotics were Amikacin, piperacillin/tazobactam, ceftazidime. Gram positive cocci were more sensitive to penicillin and quinazoline. Conclusion In this group, the changes of pathogenic microorganisms in bile were still mainly Escherichia coli, It was suggested that patients with bacterial infection of biliary tract in our city were recommended to choose and used amikacin, piperacillin/tazobactam, cefotetan.