前列地尔注射液联合丹参川芎嗪注射液治疗早期糖尿病肾病的临床观察

Clinical observation of alprostadil injection combined with Danshen Chuanxiong injection in the treatment of early diabetic nephropathy

目的观察并比较对早期糖尿病肾病患者应用前列地尔注射液联与前列地尔注射液联合丹参川芎嗪注射液治疗的临床效果。方法 70例糖尿病肾病患者,随机分为对照组与观察组,每组35例。对照组患者在常规治疗基础上联合前列地尔注射液治疗,观察组患者在对照组患者治疗的基础上联合丹参川芎嗪注射液治疗,两组患者均治疗14 d。比较两组患者治疗前后的总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、肌酐(Cr)、尿素氮(BUN)、β_2-微球蛋白(β_2-MG)、尿微量白蛋白排泄率(UAER)水平。结果治疗前,两组患者的TC、TG、HDL-C、LDL-C水平比较,差异均无统计学意义(t=0.288、0.557、1.046、1.474,P>0.05);治疗后,两组患者的TC、TG、HDL-C、LDL-C水平均优于本组治疗前,差异均具有统计学意义(P<0.05);且治疗后观察组患者的TC、TG、HDL-C、LDL-C水平均优于对照组,差异均具有统计学意义(t=7.669、3.136、2.772、2.366,P<0.05)。治疗前,两组患者的Cr、BUN、UAER、β_2-MG水平比较,差异均无统计学意义(t=0.070、0.261、0.089、1.202,P>0.05);治疗后,两组患者的Cr、BUN、UAER、β_2-MG水平均优于本组治疗前,差异均具有统计学意义(P<0.05);且治疗后观察组患者的Cr、BUN、UAER、β_2-MG水平均优于对照组,差异均具有统计学意义(t=4.768、3.010、7.136、2.366,P<0.05)。结论对早期糖尿病肾病患者联合应用前列地尔注射液及丹参川芎嗪注射液的中西医联合治疗方式效果突出,治疗后患者尿中白蛋白及β_2-MG水平明显下降,同时患者血脂水平也明显改善,该治疗方式可有效保护患者的肾脏功能,延缓糖尿病肾病的进展,值得临床推广应用。

Objective To observe and compare clinical effects by alprostadil injection,and alprostadilinjection combined with Danshen Chuanxiong injection in the treatment of early diabetic nephropathy patients.Methods A total of70patients with early diabetic nephropathy were randomly divided into control group andobservation group,with35cases in each group.The control group received additional alprostadil injection toconventional therapy,and the observation group received additional Danshen Chuanxiong injection to treatmentin the control group.Treatment in both groups lasted for14d.Comparison was made on total cholesterol(TC),triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),creatinine(Cr),blood urea nitrogen(BUN),β2-microglobulin(β2-MG),and urine albumin excretion rate(UAER)levels before and after treatment between the two groups.Results Before treatment,there was no statisticallysignificant difference of TC,TG,HDL-C,and LDL-C levels between the two groups(t=0.288,0.557,1.046,1.474,P>0.05).Both groups had better levels after treatment than those before treatment,and their differences all hadstatistical significance(P<0.05).The observation group also had better levels after treatment than the control group,and their differences all had statistical significance(t=7.669,3.136,2.772,2.366,P<0.05).Before treatment,therewas no statistically significant difference of Cr,BUN,UAER andβ2-MG levels between the two groups(t=0.070,0.261,0.089,1.202,P>0.05).Both groups had better levels after treatment than those before treatment,and theirdifferences all had statistical significance(P<0.05).The observation group also had better levels after treatment in the control group.Treatment in both groups lasted for14d.Comparison was made on total cholesterol(TC),triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),creatinine(Cr),blood urea nitrogen(BUN),β2-microglobulin(β2-MG),and urine albumin excretion rate(UAER)levels before and after treatment between the two groups.Results Before treatment,there was no statisticallysignificant difference of TC,TG,HDL-C,and LDL-C levels between the two groups(t=0.288,0.557,1.046,1.474,P>0.05).Both groups had better levels after treatment than those before treatment,and their differences all hadstatistical significance(P<0.05).The observation group also had better levels after treatment than the control group,and their differences all had statistical significance(t=7.669,3.136,2.772,2.366,P<0.05).Before treatment,therewas no statistically significant difference of Cr,BUN,UAER andβ2-MG levels between the two groups(t=0.070,0.261,0.089,1.202,P>0.05).Both groups had better levels after treatment than those before treatment,and theirdifferences all had statistical significance(P<0.05).The observation group also had better levels after treatmentthan the control group,and their differences all had statistical significance(t=4.768,3.010,7.136,2.366,P<0.05).Conclusion Combined implement of alprostadil injection and Danshen Chuanxiong injection as integratedChinese and Western medicine therapy provides excellent effect for early diabetic nephropathy patients.Patientshave obviously lowered urine albumin andβ2-MG levels,and blood lipid levels after treatment.This method can provide effective protection for renal function,and slow development of diabetic nephropathy,and it is worthclinical promotion and application.