β_1受体阻滞剂比索洛尔干预扩张型心肌病患者心率震荡和血压的效应探讨

Investigation of effect by bisoprolol as β_1 receptor blocker in intervention of heart rate turbulence and blood pressure of dilated cardiomyopathy patients blood pressure of dilated cardiomyopathy patients

目的分析β_1受体阻滞剂比索洛尔干预扩张型心肌病(DCM)患者的临床治疗效果。方法 70例扩张型心肌病患者,采取计算机随机分组方案分为常规组与实验组,每组35例。两组患者均给予比索洛尔进行治疗,常规组给予常规剂量治疗;实验组从小剂量开始,依据患者实际病情对药物剂量进行调整。对比两组治疗效果。结果治疗后,实验组窦性心率震荡的初始值(T0)(0.29±1.00)、窦性心率震荡的斜率(TS)(4.18±2.21)优于常规组的(-0.16±1.28)、(5.73±2.01),差异均具有统计学意义(P<0.05)。实验组的收缩压(113.23±9.85)mm Hg(1 mm Hg=0.133 kPa)、舒张压(75.14±10.23)mm Hg水平均低于常规组的(123.25±8.96)、(83.54±10.47)mm Hg,差异均具有统计学意义(P<0.05)。结论对扩张型心肌病患者采取比索洛尔进行治疗的疗效显著,可有效改善患者临床症状,促进生活质量的提高,改善心率震荡和血压情况,改善患者预后。

Objective To analyze clinical effect by bisoprolol asβ1receptor blocker in treatmentof dilated cardiomyopathy(DCM)patients.Methods A total of70patients with dilated cardiomyopathy wererandomly divided into conventional group and experimental group,with35cases in each group.Both groupsreceived bisoprolol for treatment,with conventional dosage in the conventional group,and small dose as startingdosage and regulation based on patients condition in the experimental group.Curative effects were comparedbetween the two groups.Results After treatment,the experimental group had better original value of sinus heart rateturbulence(T0)as(0.29±1.00)and slope of sinus heart rate turbulence(TS)as(4.18±2.21)than(-0.16±1.28)and(5.73±2.01)in the conventional group,and their differences all had statistical significance(P<0.05).The experimentalgroup had lower systolic blood pressure as(113.23±9.85)mm Hg(1mm Hg=0.133kPa)and diastolic bloodpressure as(75.14±10.23)mm Hg than(123.25±8.96)and(83.54±10.47)mm Hg in the conventional group,and their differences all had statistical significance(P<0.05).Conclusion Implement of bisoprolol showsexcellent curative effect in treating dilated cardiomyopathy patients.This method can effective improve clinicalsymptoms in patients,enhance improvement of quality of life,improve heart rate turbulence,blood pressurecondition and prognosis in patients.