黄体酮对先兆流产者孕酮水平与血清β-HCG的影响

Influence by progesterone on progesterone level and serum β-HCG in threatened abortion patients

目的了解黄体酮在黄体功能不全所致先兆流产治疗中的应用效果。方法 82例先兆流产孕妇,按照简单数字单双号顺序分为对照组和调查组,每组41例。对照组给予地屈孕酮口服治疗;调查组给予黄体酮口服治疗,对比两组孕妇各自用药后的孕酮水平与血清β-人绒毛膜促性腺激素(HCG)指标值、保胎成功率及用药期间的不良反应情况。结果两组患者用药后孕酮水平与血清β-HCG均有所改善,调查组患者改善情况优于对照组,差异具有统计学意义(P<0.05)。调查组患者保胎成功率达95.12%,明显高于对照组患者的82.93%,差异具有统计学意义(P<0.05)。调查组患者用药期间不良反应发生率为4.88%,明显低于对照组的19.51%,差异具有统计学意义(P<0.05)。结论黄体酮用于先兆流产治疗中保胎效果更好,服用方便,对母婴均无不良影响,在临床妊娠结局改善中有一定的推广应用价值。

Objective To understand application effect by progesterone in the treatment of threatenedabortion caused by luteal phase defect.Methods A total of82pregnant women with threatened abortion weredivided by odevity into control group and investigative group,with41cases in each group.The control groupreceived oral administration of dydrogesterone for treatment,and the investigate group received oral administrationof progesterone for treatment.Comparison was made on progesterone level,serumβ-human chorionicgonadotropin(HCG),success rate of fetus protection,and adverse reactions during medication between the twogroups.Results Both groups had improved progesterone level and serumβ-HCG after medication,and theinvestigate group had better improvement than the control group,and their difference had statistical significance(P<0.05).The investigate group had obviously higher success rate of fetus protection as95.12%than82.93%inthe control group,and their difference had statistical significance(P<0.05).The investigate group had much lowerincidence of adverse reactions during medication as4.88%than19.51%in the control group,and the differencehad statistical significance(P<0.05).Conclusion Implement of progesterone in treating threatened abortionshows excellent effect for fetus protection,along with convenient administration and no adverse effect on motherand infant.This method contains certain promotion and application value for improvement of clinical pregnancyoutcome.