降钙素原测定在腹腔感染疾病中的应用

Application of procalcitonin in abdominal infection disease

目的分析、比较降钙素原对于腹腔感染和肺部感染的预后判断价值。方法选择100例腹腔感染性患者以及100例呼吸系统感染性作为研究对象,在24 h内对患者进行PCT、内毒素检测,抽取动脉血测定乳酸,腹腔细菌感染者为第一组,肺部感染患者为第二组,同时按照24 h内最差临床指标来计算APACHEⅡ评分,对比、分析相同分组下不同预后患者之间PCT、内毒素、血清乳酸、APACHEⅡ评分之间的差异性;对比、分析不同分组下相同预后患者之间PCT、内毒素、血清乳酸、APACHEⅡ评分之间的差异性。结果存活组中第一组死亡了15例,存活了85例;第二组死亡了12例,存活了88例,在不同预后患者入院第1天PCT水平、血清乳酸、APACHEⅡ评分、内毒素比较中,死亡组PCT水平、血清乳酸、APACHEⅡ评分、内毒素显著高于存活组(P<0.05),而死亡组中,第一组的PCT明显高于第二组(P<0.05),血清乳酸、APACHEⅡ评分、内毒素高于第二组,两组比较差异无统计学意义。结论相较于肺部感染而言,PCT对判断腹腔细菌感染具有更大的价值,能够准确如实地对细菌感染性疾病的程度进行反映,其结果对患者疾病的诊断以及预后评估具有一定的指导意义,值得临床进一步推广。

Objective To analysis and comparison of the calcitonin original the prognostic value of the abdominal cavity infection and pulmonary difference.Methods100patients with abdominal infection and100cases of respiratory infection were selected as subjects,to extract in patients with24h,including PCT,endotoxin,arterial blood lactate,abdominal cavity bacterial infection into the first group,pulmonary infection patients into second groups,according to24h in the worst clinical index to calculate the APACHE score,the comparison and analysis of the same group of patients with different prognosis between PCT and endotoxin,serum lactate and APACHE score between the difference;comparison and analysis of differences between different groups[under the same prognosis of patients with PCT,serum endotoxin,lactic acid,APACHE score of statistical methods.Results In the first group survival group died in15cases,85cases survived;second died in group12cases,88cases of survival in patients with different prognosis first days after admission,serum PCT levels of lactate and APACHE score,endotoxin,PCT,serum lactic acid level of death group,APACHE score was significantly higher than that in the toxin,the survival group(P<0.05),while in the death group,the first group of PCT was significantly higher than that of the second groups(P<0.05),serum lactic acid,endotoxin,APACHE score higher than that of group second,two groups had no statistically significant difference.Conclusion Calcitonin original value for clinical judgment bacterial infections has great promoting effect,can accurate faithfully to reflect the extent of the with bacterial infectious diseases,the results to evaluate the diagnosis and prognosis of patients with disease have a certain guiding significance,is worth further promotion in the clinical practice.