BAP1及其抑癌作用研究新进展

Research advance on BAP1 and its function in tumor suppression

BAP1是泛素羧基末端水解酶家族中的一员,其基本功能是去除底物蛋白质的泛素化修饰。BAP1还是多种细胞功能调控的关键分子,通过依赖或不依赖其去泛素化功能,调节基因表达、细胞周期、细胞分化、细胞凋亡和DNA损伤应答等。由于BAP1在细胞内的重要作用,其基因突变或表达水平的下调能够显著提高多种肿瘤的易患性,但具体的致病机制目前尚不清楚,有待进一步的研究,这也为未来肿瘤治疗带来新的契机。

BAP1is a member of the ubiquitin C-terminal hydrolases(UCH)subfamily of deubiquitylases with basic function of removing monoubiquitin or ubiquitin chains from the specific substrate proteins.As well,it is a key factor in regulating gene expression,cell cycle,cell differentiation,cell apoptosis and DNA damage response,dependent or independent of its deubiquitination function.Evidences have revealed that mutation or downregulation of BAP1can prominently increase the occurrence of cancers,including uveal melanoma,mesothelioma,renal cell carcinoma,breast cancer and lung cancer.Currently,the tumor spectrum and the pathogenic mechanism on BAP1have not been illustrated clearly,and need to be further researched,which might bring a new opportunity in treatment of cancers.