抗过敏药物盐酸松齐拉敏的合成

Synthesis of Anti-allergic Medicine Hydrochloric Acid Thonzylamine

抗过敏药物是医院日常医疗过程中比较常用的一种药物,对患者病情的康复有着重大作用,不仅是医院,就连小的诊所和药店里面也广泛应用到了抗过敏药物。抗过敏药物的种类繁多,不同的抗敏药物其抗敏效果不一样,有时为了更好的治疗疾病,减轻患者的病痛,医院会利用多种药物合成更有利于患者治疗的新型抗过敏药物,盐酸松齐拉敏就是一种常见的合成抗过敏药物,合成的原料包括2-氨基嘧啶、对甲氧基氯苄和N,N-二甲基-2-氯乙胺,其合成步骤为两次N-烃基化反应,其合成后的总收率为79.2%,最终合成功的结构要通过~1H NMR,^(13)C NMR和HR-MS(ESI)确证。

Anti-allergic medicine is the common used medicine in hospitals’daily medical process and has important function on the recovery of patients,besides,it not only has application in hospitals,but also in small clinics and pharmacies.The drug categories are of a great variety and the anti-allergic effect of different anti-allergic medicines is different,sometimes,in order to better treat the isease and release patients’pain,the hospital will use many kinds of medicines to make new-type anti-allergic synthetic medicine that is more helpful to patients.Hydrochloric acid is one common seen synthetic anti-allergic medicine and its synthetic materials include2-aminopyrimidine,methoxybenzyl chloride and N,N-dimethyl-2-chloroethylamine,besides,its synthetic step is two-time N-alkylation,which total recovery rate after synthesis is79.2%,finally,the structure of synthetic work needs to be confirmed by1HNMR,13C NMR and HR-MS(ESI).