地屈孕酮与黄体酮治疗先兆流产的疗效分析

Analysis of the efficacy of dydrogesterone and progesterone in the treatment of threatened abortion

目的:分析地屈孕酮与黄体酮治疗先兆流产的疗效。方法:收治先兆流产孕妇128例,随机平分两组。观察组采用地屈孕酮治疗,对照组采用黄体酮治疗,比较两组的临床疗效及不良反应发生率。结果:两组治疗后孕7周、孕8周血清孕酮水平均高于孕6周,孕8周血清孕酮水平均高于孕7周,差异有统计学意义(P<0.05),两组间比较差异均无统计学意义(P>0.05);观察组保胎成功率、新生儿畸形率、不良反应发生率与对照组比较,差异均无统计学意义(P>0.05)。结论:地屈孕酮和黄体酮治疗先兆流产,效果相当,临床可结合患者需要酌情考虑治疗方案。

Objective:To analyze the efficacy of dydrogesterone and progesterone in the treatment of threatened abortion.Methods:128patients with threatened abortion were selected.They were randomly divided into the two groups on average.The observationgroup was treated with dydrogesterone.The control group was treated with progesterone.The clinical efficacy and incidence ofadverse reactions were compared between groups.Results:After treatment,the progesterone levels at7and8weeks of gestationwere higher than at6weeks,and the serum progesterone levels were higher in8weeks after pregnancy than those in7weeks;thedifferences were statistically significant(P<0.05);there was no significant difference between groups(P>0.05).There was nosignificant difference in the incidence of neonatal malformation,and the incidence of neonatal malformations and the incidence ofadverse reactions in the observation group compared with the control group(P>0.05).Conclusion:Dydrogesterone andprogesterone in the treatment of threatened abortion has considerable effect.In clinic,we can consider the treatment plan accordingto the patient's need.