盐酸氨溴索联合鼻塞式持续正压通气治疗新生儿肺炎的效果观察

Observation on effect of ambroxol hydrochloride combined with nasal continuous positive airways pressure in the treatment of neonatal pneumonia

目的探究盐酸氨溴索联合鼻塞式持续正压通气治疗新生儿肺炎的效果。方法 100例新生儿肺炎患儿作为研究对象,随机分为对照组与观察组,每组50例。对照组予以鼻塞式持续正压通气治疗,观察组予以盐酸氨溴索联合鼻塞式持续正压通气治疗。治疗后,对比两组的临床疗效、血气指标、肺部啰音消失、住院时间及鼻塞式持续正压通气治疗时间。结果观察组的治疗总有效率(94.00%)高于对照组(76.00%),差异具有统计学意义(P<0.05)。治疗前两组动脉血氧分压、氧合指数及动脉血二氧化碳分压比较差异均无统计学意义(P>0.05);治疗后观察组动脉血氧分压、氧合指数及动脉血二氧化碳分压均优于对照组,差异均具有统计学意义(P<0.05)。观察组患儿肺部啰音消失时间、住院时间及鼻塞式持续正压通气治疗时间均短于对照组,差异均具有统计学意义(P<0.05)。结论对新生儿肺炎患儿予以盐酸氨溴索联合鼻塞式持续正压通气进行治疗效果确切,可以明显改善患儿的心肺功能,缩短住院时间。

Objective To explore the effect of ambroxol hydrochloride combined with nasal continuouspositive airways pressure in the treatment of neonatal pneumonia.Methods A total of100pneumonia newbornsas study subjects were randomly divide into control group and observation group,with50cases in each group.Thecontrol group received nasal continuous positive airways pressure for treatment,and the observation group receivedambroxol hydrochloride combined with nasal continuous positive airways pressure for treatment.After treatment,comparison were made on clinical curative effect,blood gas indexes,lung rale disappearance time,hospitalstay time and nasal continuous positive airway pressure treatment time in two groups.Results The observationgroup had higher total treatment effective rate as94.00%than76.00%in the control group,and the differencehad statistical significance(P<0.05).Before treatment,both groups had no statistically significant difference inarterial partial pressure of oxygen,oxygenation index and partial pressure of carbon dioxide in artery(P>0.05).After treatment,the observation group had better arterial partial pressure of oxygen,oxygenation index and partialpressure of carbon dioxide in artery than the control group,and their difference had statistical significance(P<0.05).The observation group had shorter lung rale disappearance time,hospital stay time and nasal continuous positiveairway pressure treatment time than the control group,and their difference had statistical significance(P<0.05).Conclusion Combination of ambroxol hydrochloride and nasal continuous positive airways pressure showsaffirmative therapeutic effect in treating pneumonia newborns,and it can obviously improve cardio-pulmonaryfunction of newborns and shorten hospital stay time.