生长抑素联合乌司他丁治疗消化道出血的临床疗效观察

Observation on clinical curative effect of somatostatin combined with ulinastatin in the treatment of alimentary tract hemorrhage

目的分析生长抑素联合乌司他丁治疗消化道出血的临床疗效。方法 163例消化道出血患者,采用随机数字表法分为观察组(81例)和对照组(82例)。对照组患者采用生长抑素治疗,观察组患者采用生长抑素联合乌司他丁治疗。比较两组患者治疗前后的炎症因子[白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-ɑ)]水平、临床疗效、止血时间、住院时间。结果治疗前,两组患者的IL-2、IL-6、TNF-ɑ水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者的IL-2明显升高,IL-6、TNF-ɑ明显降低,且观察组患者的IL-2高于对照组,IL-6、TNF-ɑ低于对照组,差异均具有统计学意义(P<0.05)。观察组总有效率97.53%高于对照组82.93%,差异有统计学意义(P<0.05)。观察组患者的止血时间为(19.36±3.41)h,住院时间为(5.63±2.06)d;对照组患者的止血时间为(32.47±5.26)h,住院时间为(10.25±3.21)d;观察组止血及住院时间均短于对照组,差异均有统计学意义(P<0.05)。结论与单纯使用生长抑素治疗相比,联合乌司他丁治疗能显著改善患者的炎性反应,提高机体免疫力,促进患者病情改善,提高治疗效果。

Objective To analyze the clinical curative effect of somatostatin combined with ulinastatinin the treatment of alimentary tract hemorrhage.Methods A total of163alimentary tract hemorrhage patientswere divided by random number table method into observation group(81cases)and control group(82cases).Thecontrol group received somatostatin for treatment,and the observation group received somatostatin combined withulinastatin for treatment.Comparison were made on inflammatory factor[interleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-ɑ)]level before and after treatment,clinical curative effect,hemostatictime and hospital stay time in two groups.Results Before treatment,both groups had no statistically significantdifference in IL-2,IL-6and TNF-ɑlevel(P>0.05).After treatment,both groups had obviously higher IL-2,and obviously lower IL-6and TNF-ɑ.The observation group had higher IL-2than the control group,andlower IL-6and TNF-ɑthan the control group.Their difference had statistical significance(P<0.05).Theobservation group had higher total effective rate as97.53%than82.93%in the control group,and the differencehad statistical significance(P<0.05).The observation group had hemostatic time as(19.36±3.41)h,hospital staytime as(5.63±2.06)d,while the control group had hemostatic time as(32.47±5.26)h and hospital stay timeas(10.25±3.21)d.The observation group had shorter hemostatic time and hospital stay time than the controlgroup,and the difference had statistical significance(P<0.05).Conclusion Compared with somatostatin only,combination of ulinastatin therapy can significantly improve inflammatory reaction of patients,increase immunity,promote medical improvement and enhance the therapeutic effect.