阿扎司琼与昂丹司琼预防白血病患者化疗后恶心呕吐的疗效和不良反应对比

Comparison on curative effect and adverse reactions of azasetron and ondansetron in prevention of nausea and vomiting in leukemia patients after chemotherapy

目的探索阿扎司琼与昂丹司琼对预防白血病患者化疗后恶心呕吐的效果以及安全性。方法 52例白血病化疗患者为研究对象,随机将患者分成A组和B组,各26例。A组预防性应用阿扎司琼,B组预防性应用昂丹司琼,比较两组患者恶心呕吐及不良反应发生情况。结果 A组患者的恶心呕吐发生率为11.54%,B组患者的恶心呕吐发生率为15.38%,比较差异无统计学意义(P>0.05);两组恶心呕吐的严重程度分级比较差异无统计学意义(P>0.05)。A组患者的不良反应发生率为11.54%,明显低于B组患者的34.62%,差异有统计学意义(P<0.05)。结论阿扎司琼与昂丹司琼对预防白血病化疗患者恶心呕吐均能取得较好的效果,但是阿扎司琼的安全性更高,患者更易耐受,有助于保证化疗的顺利开展,提高患者的生存质量,值得推广应用。

Objective To explore the effect and safety of curative effect and adverse reactions ofazasetron and ondansetron in prevention of nausea and vomiting in leukemia patients after chemotherapy.MethodsA total of52leukemia patients with chemotherapy as study subjects were randomly divided into group A andgroup B,with26cases in each group.Group A received azasetron,and group B received ondansetron.Comparisonwere made on occurrence of nausea and vomiting and adverse reactions in two groups.Results Group A hadincidence of nausea and vomiting as11.54%,while group B had incidence of nausea and vomiting as15.38%,andthe difference had no statistical significance(P>0.05).Both groups had no statistically significant difference inseverity of nausea and vomiting(P>0.05).Group A had obviously lower incidence of adverse reactions as11.54%than34.62%in group B,and the difference had statistical significance(P<0.05).Conclusion Both azasetron andondansetron shows good effect in prevention of nausea and vomiting in leukemia patients with chemotherapy,butazasetron is safer and easier to tolerate,which helps to ensure the smooth progress in chemotherapy and improvethe patients’quality of life.So it is worth popularization and application.