活血化瘀法对骨科围手术期F1+2、D-二聚体影响研究

Clinical effects of the Huoxue Huayu therapy on levels of plasma F1+2 and D-dimer in orthopedic perioperative patients

目的:通过动态观察活血化瘀法治疗后骨科围手术期患者凝血相关指标情况,了解活血化瘀法对骨科围手术期凝血功能的影响。方法:选择80例股骨骨折且行内固定手术治疗的患者,随机分为中药组和对照组,中药组每日服桃红四物汤1包,连续用药2周,两组均从术后第1天起予一般性预防措施,例如术前术中适当补液,术后第2天开始全部患者均使用机械方法预防血栓,如间歇充气加压装置每天2次,对所有研究对象空腹血浆中的F1+2、D-二聚体浓度进行监测,并进行对比研究。结果:两组患者术后血浆F1+2浓度、D-二聚体明显升高(P<0.05)。中药组与对照组相比,T3及T4时点的血浆F1+2、D-二聚体水平明显下降(P<0.05)。两组DVT发病率无统计学差异(P>0.05)。结论:活血化瘀法对改善术后高凝状态具有一定作用,对预防深静脉血栓具有一定意义。

Objective:To observe clinical effects of the Huoxue Huayu therapy on the levels of plasma F1+2and D-dimer in orthopedicperioperative patients.Methods:80patients who had received orthopedic surgery were randomly divided into the TCM medicine group andcontrol group.The TCM medicine group was treated with the Taohong Siwu decoction,for2weeks.Both groups were given conventionalprevention measure after surgery.Results:The contents of plasma D-dimer and F1+2in all cases were increased significantly(P<0.05).The level of D-dimer and F1+2in the TCM medicine group was decreased at T3and T4,P<0.05.There was no significant difference of theincidence rate of DVT between the groups.Conclusion:The Huoxue Huayu therapy can relieve hypercoagulability and prevent from DVT.