桃红二芍汤对血瘀型寻常型银屑病临床疗效及血清免疫细胞的影响

Clinical efficacy of the Taohong Ershao decoction on psoriasis of the Xueyu type and the influence on serum immune cells

目的:血瘀型寻常型银屑病患者服用桃红二芍汤,对治疗银屑病的临床疗效进行分析及探讨对血清免疫细胞的影响。方法:选取我院血瘀型寻常型银屑病患者104例,采用随机分配法,分为对照组及治疗组,每组52例。对照组给予常规的阿维A药物治疗,治疗组在此基础上用桃红二芍汤进行治疗,比较治疗前后银屑病的皮损面积和严重度指数评分及记录起效时间和复发时间,并测定血清免疫细胞因子水平。结果:与对照组相比较,治疗组患者的皮损面积和严重度指数评分均较阿维A对照组明显降低,组间差异具有显著性(P<0.05)。治疗后治疗组患者起效时间较对照组起效时间要延迟,复发率降低。治疗组的CD4+、CD4+/CD8+水平较对照组明显升高(P<0.05)。而CD8+水平在治疗前与治疗后无明显差异性(P>0.05)。结论:桃红二芍汤可明显降低血瘀型寻常型银屑病患者的皮损面积和严重度评分,有效改善血清免疫细胞水平,虽中药汤剂起效时间较长,但复发率降低,在临床治疗中可应用。

Objective:To investigate efficacy of the Taohong Ershao decoction on psoriasis of the Xueyu type and the influenceon serum immune cells.Methods:104patients were divided into2groups,52cases for each.The control group was given Acitretin;the treatment group was given the Taohong Ershao decoction more.After treatment,the lesion area of the psoriasis,the severity index score,the onset time,the recurrence time were compared;and the level of serum immunocytokines was determined.Results:The lesion area andseverity index in the treatment group were significantly lower than those in the control group(P<0.05).The onset time in the treatmentgroup was shorter than that in the control group,and the recurrence rate was decreased.The levels of CD4+,CD4+/CD8+in the treatmentgroup were significantly higher than those in the control group(P<0.05).But there was no significant change in CD8+level(P>0.05).Conclusion:The Taohong Ershao decoction can significantly reduce the lesion area and severity score,effectively improve the level ofserum immune cells,reduce the recurrence rate,and is worthy of application.