理想的基础胰岛素:每日一次,安全达标

Ideal Basal Insulin is Injected Once Daily,and can Achieve Blood Glucose Targets Safely and Effectively

基础胰岛素在临床上应用广泛,众多指南推荐其为胰岛素起始治疗方案之一。掌握基础胰岛素的规范使用方法,对提高临床医生使用胰岛素的水平及血糖达标率将大有裨益。理想的基础胰岛素应每日一次注射即可实现安全达标,但部分临床医生对有关地特胰岛素在临床上的使用次数和效果仍然存在一定的疑问。本文从分子结构、药代学、药效学和临床试验等方面论证,地特胰岛素1天1次可安全优效使血糖达标。地特胰岛素可认为是一种较为理想的基础胰岛素。

Basal insulin is widely used in clinic,and many guidelines recommend it as one of the initial treatment of insulin.Mastering the correct use of basal insulin can promote the clinical treatment ability of doctors and improve the blood glucose control of patients.The ideal basal insulin is injected once daily,and can achieve blood glucose targets safely and effectively.But some clinicians have some questions about the clinical effect and injection number of insulin detemir.The molecular structure,pharmacokinetics,pharmacodynamics characteristics and clinical trials have shown that once daily insulin detemir is safe and effective,and can achieve good glucose control.Insulin detemir can be considered as an ideal basal insulin.