2型糖尿病早期强化胰岛素治疗效果观察

Effect of Early Intensive Insulin Therapy in Type 2 Diabetes Mellitus

目的:探讨2型糖尿病患者早期强化胰岛素治疗的效果。方法:选取周口市中心医院2014年10月至2015年10月诊治的2型糖尿病患者262例,采用随机数字表法分为两组,对照组患者131例采用阿卡波糖治疗,观察组患者131例采用早期强化胰岛素治疗,比较两组患者治疗前后血糖改变情况、胰岛素功能改善情况,分析两组患者的临床转归。结果:治疗后,两组患者空腹血糖、餐后2h血糖、糖化血红蛋白、胰岛素抵抗指数降低(P<0.05)。两组患者胰岛素分泌指数、胰岛素敏感指数升高(P<0.05)。观察组患者空腹血糖、餐后2h血糖、糖化血红蛋白、胰岛素抵抗指数、低血糖发生率、胰岛素治疗比例低于对照组(P<0.05)。观察组患者胰岛素分泌指数、胰岛素敏感指数、停药比例、口服降糖药比例高于对照组(P<0.05)。观察组患者血糖达标时间早于对照组(P<0.05)。结论:2型糖尿病患者早期强化胰岛素治疗的效果显著,预后较好,值得临床推广使用。

Objective:To investigate effect of early intensive insulin therapy in type2diabetes mellitus.Methods:262patients with type2diabetes mellitus selected in hospital from October2014to October2015were divided into two groups by random number table method,131patients treated acarbose as control group,131patients treated early intensive insulin therapy as observation group.Changes of blood glucose and improvement of insulin function were compared between two groups before and after treatment.Clinical outcome was analyzed in two groups.Results:After treatment,fasting blood glucose,postprandial2h blood glucose,glycosylated hemoglobin,insulin resistance index decreased in two groups(P<0.05).Insulin secretion index,and insulin sensitivity index increased in two groups(P<0.05).Fasting blood glucose,postprandial2h blood glucose,glycosylated hemoglobin,insulin resistance index,incidence of hypoglycemia,insulin treatment ratio in observation group were lower than control group(P<0.05).Insulin secretion index,insulin sensitivity index,proportion of drug withdrawal,proportion of oral hypoglycemic drugs in observation group were higher than control group(P<0.05).Blood glucose compliance time in observation group was earlier than control group(P<0.05).Conclusion:Early intensive insulin therapy has significant effect in treatment for type2diabetes mellitus.Prognosis is good.That is worthy of clinical application.