一步法合成3-苯甲酰基-5,7-二羟基黄酮及其合成条件的优化

One-step Synthesis of 3-benzoyl-5,7-dihydroxyflavone and Optimization of Synthetic Conditions

以2,4,6-三羟基苯乙酮和苯甲酰氯为原料,一步反应合成到了高产率的3-苯甲酰基-5,7-二羟基黄酮,目标产物的结构用1HNMR、ESI-MS进行了表征,采用正交试验对合成工艺进行了优化,得到的最佳合成工艺为:吡啶和2,4,6-三羟基苯乙酮的摩尔数之比为4∶1,碳酸钾和2,4,6-三羟基苯乙酮的摩尔数之比为8∶1,反应温度60℃,该方法可经济、方便的合成3-苯甲酰基-5,7-二羟基黄酮.

3-benzoyl-5,7-dihydroxyflavone was synthesized with2,4,6-Trihydroxyacetophenone and benzoylchloride as starting materials by a onet-step reaction in dry acetone in the presence of potassium carbonate andpyridine,and the structures of the synthesized compound was confirmed by1H NMR and ESI-MS spectroscopy.Thesynthesis process was optimized by using orthogonal design.The optimal synthesis process conditions obtained byexperiments were as follows,the ratio of the moles number of2,4,6-Trihydroxyacetophenone,potassium carbonateand pyridine was1∶4∶8,and the reaction temperature was60℃.This method can be used for economic andconvenient synthesis of3-benzoyl-5,7-dihydroxyflavone.