妊晚期孕妇血清HCY、叶酸、维生素B 12检测与分析

Detection and Analysis of the HCY, Folic Acid and Vitamin B12 in Serum of 143 Late Pregnancy Women

目的探讨妊娠晚期血清中Hcy与叶酸、V-B12、血糖和血压之间的关系。方法选取143例妊娠晚期孕妇作为研究对象,检测并比较HCY、叶酸、V-B12、血糖和血压之间的关系。结果血清Hcy与孕妇年龄无关;重度高Hcy血症的孕妇血清叶酸水平降低;随着Hcy的升高,空腹血糖和收缩压及舒张压有不同程度的增高;正常妊娠组的血清HCY与糖尿病组、高血压组、低叶酸血症组、低V-B12血症组比较有显著差异;通过皮尔逊相关分析发现,血清HCY与叶酸和V-B12呈负正相关;HCY与空腹血糖、收缩压和舒张压呈正相关;空腹血糖与收缩压和舒张压呈正相关。结论妊娠期血清Hcy的水平增高不容忽视,是引发妊娠期高血压、妊娠期糖尿病和不良妊娠的主要因素。

Objective To investigate the relationship among HCY,folic acid,Vitamin B12,blood glucose and blood pressure Methods Take143women with late pregnancy treated in our hospital as study objects,detected and compared the relationship among HCY,folic acid,Vitamin B12,blood glucose and blood pressure.Results There is no marked relationship between HCY in serum andpregnant women′s age;the level of folic acid was decreased in pregnant women with severe hyperhomocysteinemia(P<0.01);fasting blood glucose,systolic pressure and diastolic blood pressure was increased at different degrees with the increase of Hcy;Pearson correlation analysis showed that there are negative correlation between HCY in serum and folic acid,there are positive correlation between HCY in serum and Vitamin B12(P<0.01,P<0.05);there are positive correlation between HCY in serum and fasting blood glucose,systolic pressure,diastolic blood pressure(P<0.01);there are positive correlation between fasting blood glucose and systolic pressure,diastolic blood pressure(P<0.05).Conclusion The increase of Hcy in serum during the pregnancy period is indispensable,it is the main factor that induce gestational hypertension,gestational diabetes and adverse pregnancy.