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复杂动态微环境中多成分的肿瘤生长对流扩散反应模型

Convection Diffusion Reaction Model of Tumor Growth in Complex Dynamic Environment
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摘要 主要针对可生长和坏死的肿瘤细胞,以及正常组织细胞、细胞间质等多成分之间的相互作用和演变关系进行了分析.在肿瘤细胞的迁移模型基础上,考虑了细胞外基质(ECM)的降解和基质降解酶(MDEs)的运输条件,构建了一个复杂动态微环境中的肿瘤生长对流扩散反应模型,并对此进行了仿真模拟分析. We analyzed the growth and necrosis of tumor cells,interaction and evolution and the relationship between thenormal tissue cells,interstitial cells and other components.Based on the model of migration of tumor cells,we considered theextracellular matrix(ECM)degradation and matrix degradation enzymes(MDEs)transport conditions and constructed a convectiondiffusion reaction model tumor growth in a complex dynamic microenvironment,and make simulation analysis.
作者 黄雪玲 王振友 HUANG Xueling;WANG Zhenyou(School of Applied Mathematics, Guangdong University of Technology, Guangzhou 510520, China)
机构地区 广东工业大学应用数学学院
出处 《湖南理工学院学报（自然科学版）》 CAS 2017年第2期16-22,共7页 Journal of Hunan Institute of Science and Technology(Natural Sciences)
关键词 微环境成分 固体肿瘤生长 质量守恒 反应扩散方程 microenvironmental components, solid tumor growth, mass conservation, reaction diffusion equation
分类号 O29 [理学—应用数学] R730.2 [医药卫生—肿瘤]
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湖南理工学院学报（自然科学版）
2017年 第2期

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