乌司他丁改善肾综合出血热血管损伤的临床效果评价

The clinical evaluation of ulinastatin on improvement of renal syndrome hemorrhagic fever with small vascular injury

目的:探究乌司他丁对改善肾综合出血热引起的毛细血管损伤而发生异常渗漏的临床治疗效果。方法:根据随机数字表将50例肾综合出血热的患者分为两组。给予实验组患者(25例)乌司他丁治疗;给予对照组(25例)5%糖溶液,作为空白对照。此外,根据实验组中患者就诊时发热时间分为两组。实验组A(9例)为发热1~4 d;实验组B(16例)为发热5~7 d。所有患者均在治疗后7 d后进行尿微量蛋白、血肌酐和血浆白蛋白等临床指标测定并对比。结果:与对照组相比,实验组尿微量蛋白下降显著;血肌酐恢复速度更快;血浆白蛋白上升明显;发生尿少症状的时间明显减少;并发症发生时间也明显减少;均P<0.05,差异有统计学意义。与实验组B对比,实验组A尿微量蛋白下降显著;血肌酐恢复速度更快;血浆白蛋白上升明显;并发症发生时间也明显减少;均P<0.05,差异存在统计学意义。结论:乌司他丁能有效治疗毛细血管渗漏综合征,并且在发热早期应用效果最佳。

Objective To explore the clinical effect of ulinastatin on capillary injury improvement of renalsyndrome hemorrhagic fever and renal leakage.Methods Patients were divided into2groups according to therandom number table.The experimental group(25cases)was given with ulinastatin and the control group(25cases)was given5%sugar solution as a blank control.All patients were treated with nutritional support,rehydration,prevention of bleeding and other symptoms.In addition,according to the number of days of fever in the experimentalgroup,the patients were divided into two groups.The experimental group A(9cases)had fever1~4days;theexperimental group B(16cases)had fever5~7days.All patients were measured in microalbuminuria,serumcreatinine,plasma albumin and other clinical indicators after7day treatment.Results Compared with the controlgroup,microalbuminuria of the experimental group was significantly decreased;Creatinine recovery rate was fasterthan that in the control group;Plasma albumin had significantly increased;The number of symptomatic days ofconcurrent perfusion of other tissues had also significantly reduced.Compared with the experimental group B,microalbuminuria of the experimental group A was significantly decreased;Creatinine recovery rate was faster thanthat in the experimental group B;Plasma albumin had significantly increased;The number of symptomatic days ofconcurrent perfusion of other tissues was also significantly reduced.Conclusion Ulinastatin could effectively treatvascular injury and syndrome due to capillary leakage caused by epidemic hemorrhagic fever virus,and the besteffect occurs in early application in the fever.