血维生素D水平与超声评价颈动脉硬化斑块稳定性的相关性分析

Correlative analysis of serum vitamin D level and ultrasonographic evaluation of carotid atherosclerotic plaque stability

目的分析血维生素D水平对颈动脉硬化斑块稳定性的影响。方法研究包括对照组50例，颈动脉硬化斑块稳定组42例及斑块不稳定斑块组123例。稳定组与不稳定组的区分以超声检查为依据。电化学发光法测定各组血清25-羟维生素D3水平，分析组间及组内差异。结果对照组、稳定组及不稳定组血维生素D水平分别为（89.26±32.85）nmol/l，（82.32±23.73）nmol/l及（44.10±8.09）nmol/l。斑块组及对照组血维生素D水平差异有统计学意义，P<0.05；不稳定斑块组血维生素D水平低于对照组及稳定斑块组，P<0.05；与对照组比较，稳定斑块及不稳定斑块组超声声像图存在显著特点。结论血维生素D水平可用于反应颈动脉硬化斑块的稳定性，可能为颈动脉硬化斑块的干预治疗提供了新的实验基础。

Objective The effect of serum vitamin D level on stability of carotid atherosclerotic plaque were investigated.Methods50healthy adults were involved as control group,165patients with carotid atherosclerotic plaque were enrolled in as experimental group and allocated as plaque stable group(n=42)and unstable group(n=123)by US.Serum25OHD3of all subjects were determined and the differences were statistically analyzed.Results25OHD3of each group were89.26±32.85,82.32±23.73,and44.10±8.09nmol/l.It showed statistically significant between control group and experimental group(p<0.05),while also different between plaque stable group and unstable group(p<0.05).Compared with control group,there were significant features in ultrasonography of the experimental group.Conclusion The level of25OHD3can be used to respond to the stability of carotid atherosclerotic plaque,which may provide a new experimental basis for the intervention of carotid atherosclerotic plaque.