青年女性进展型缺血性脑卒中与载脂蛋白A1、载脂蛋白B及颈动脉粥样硬化关系的研究

Relationship between youth female progressive ischemic stroke and apolipoprotein A1/apolipoprotein B/carotid atherosclerosis

目的探讨青年女性进展型缺血性脑卒中与载脂蛋白A1(Apo A1)、载脂蛋白B(Apo B)及颈动脉粥样硬化的关系。方法选取女性进展型缺血性脑卒中患者88例,其中青年40例(观察组)、老年(对照组)48例。检测患者空腹血清Apo A1、Apo B水平,并行颈动脉超声检查评估患者颈动脉粥样硬化(CAS)的发生情况。结果与对照组相比,观察组的Apo B水平显著升高(P=0.010),Apo A1/Apo B比值显著降低(P=0.028)。观察组患者的颈总动脉内-中膜厚度(IMT)较对照组显著升高(P<0.001),且其CAS发生率显著高于对照组(P=0.18)。结论对比老年女性,存在Apo B水平升高和CAS的青年女性患者更易出现进展型缺血性脑卒中,在临床中应重视此类患者,早期采取措施防治缺血性脑卒中。

Objective To explore the relationship between youth female progressive ischemic stroke and apolipoprotein A1(Apo A1)/apolipoprotein B(Apo B)/carotid atherosclerosis(CAS).Methods88female progressive ischemic arterial thrombosis patients were contained in the study,including40youth in the observed group and48elderly in the control group.The serum Apo A1and Apo B were examined.The ultrasound was used to evaluate the CAS of the patients.Results Compared with control group,Apo B of observed group was significantly higher(P=0.010),while Apo A1/Apo B ratio was significantly lower(P=0.028).The intima-media thickness(IMT)of criteria carotis communis(P<0.001)and incidence rate of CAS in observed group were obviously higher versus control group(P=0.018).Conclusion Compared with the elderly female,the young female with high Apo B and CAS were easier to suffer progressive ischemic arterial thrombosis.