59例妊娠期梅毒母婴结局分析

Study on the pregnancy outcomes of 59 cases of pregnant syphilis patients

目的分析晋江市医院梅毒母婴传播阻断的干预效果。方法回顾性分析晋江市医院产科2012~2014年59例住院妊娠合并梅毒孕妇,其中首次诊断孕周≤14周并进行规范化治疗的36例为治疗组,首次诊断孕周>14周或未进行规范化治疗的23例为对照组,根据梅毒RPR滴度将研究对象分为两组,以RPR1:16分界,21例≥1:16的为高滴度组,38例<1:16的为低滴度组,分析梅毒孕产妇的妊娠结局及婴幼儿随访情况。结果治疗组与对照组不良围产妊娠结局发生率、先天梅毒儿发生率的差异具有统计学意义,高滴度组和低滴度组不良围产妊娠结局发生率、先天梅毒儿发生率的差异具有统计学意义(P<0.05)。结论对妊娠合并梅毒患者及早进行规范化治疗,可降低不良妊娠结局发生率,并可降低先天梅毒发生率,梅毒抗体高滴度是婴儿先天梅毒的高危因素。

Objective To explore the pregnancy outcomes of pregnant syphilis patients in Jinjiang Hospital.Methods59cases of pregnancy with syphilis in pregnant women in Jinjiang Hospital from2012to2014were retrospectively analyzed,including diagnosis of gestational age14weeks or less for the first time and standardized treatment of36cases for treatment group,for the first time in the diagnosis of gestational age more than14weeks or not standardized treatment of23cases for control group,and according to the degree of syphilis RPR drop the object of study is divided into two groups,with RPR1:16boundary,21cases of1:16or for high-titer group,38cases<1:16for low-titer group,analysis of syphilis maternal pregnancy outcomes and infant follow-up.Results Treatment group and control group among the incidence of pregnancy outcome,the differences between the incidence of congenital syphilis and statistically are significant,high-titer group and low-titer drops group among the incidence of pregnancy outcome,the differences between the incidence of congenital syphilis and statistically are significant(P<0.05).Conclusion To standardized treatment of pregnancy with syphilis patients with early can reduce the incidence of adverse pregnancy outcomes,and can reduce the incidence of congenital syphilis,syphilis antibodies of high degree are high risk factors of the congenital syphilis.