大黄消痔栓直肠给药联合四环素片治疗纳米细菌致Ⅲ型前列腺炎临床研究

Clinical Study on Dahuang Xiaozhi Suppository Combined with Tetracycline in Treating Type Ⅲ Prostatitis Infected with Nano-bacteria

目的探讨大黄消痔栓联合四环素片治疗纳米细菌致Ⅲ型前列腺炎的临床疗效。方法选取纳米细菌致Ⅲ型前列腺炎患者120例,随机分为治疗组和对照组各60例。2组均停用抗感染药及其他相关制剂,进行饮食及生活干预。2组均予四环素片,每次1片,每日2次,口服。治疗组并予大黄消痔栓,每次1粒,每日1次,置入肛门3~4 cm。均10 d为1个疗程,连续3个疗程。观察2组临床疗效、主要症状改善时间及治疗前后美国国立卫生研究院慢性前列腺炎症状积分指数(NIH-CPSI),检测前列腺液(EPS)白细胞、卵磷脂小体数量、尿流率及肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-8水平。结果治疗组总有效率为100.0%(60/60),对照组为83.3%(50/60),治疗组优于对照组(P<0.05)。治疗组骨盆疼痛、排尿症状、阴囊潮湿改善时间均低于对照组(P<0.05)。与治疗前比较,2组治疗后NIH-CPSI疼痛评分、排尿症状评分、生活质量评分及总分,EPS白细胞、TNF-α、IL-6、IL-8水平均降低(P<0.05),卵磷脂小体+++^++++者增多(P<0.05),尿流率提高(P<0.05);治疗后治疗组NIH-CPSI疼痛评分、排尿症状评分、生活质量评分及总分,EPS白细胞、卵磷脂小体++++者及TNF-α、IL-6、IL-8水平与对照组比较,差异有统计学意义(P<0.05)。结论大黄消痔栓可提高四环素片治疗纳米细菌致Ⅲ型前列腺炎的临床疗效,减轻前列腺炎症。

Objective To investigate the clinical efficacy of Dahuang Xiaozhi Suppository combined with tetracycline in treating typeⅢprostatitis infected with nano-bacteria.Methods Totally120patients of typeⅢprostatitis infected with nano-bacteria were randomly divided into treatment group and control group,with60cases in each group.Both groups were disabled anti-infective drugs and other preparations for diet and life intervention.Both groups received tetracycline,once a tablet,twice a day,orally.The treatment group received Dahuang Xiaozhi Suppository,once a capsule,once a day,placing in the anus3-4cm.10d was a treatment course,for3courses.The clinical efficacy,major symptoms improving time,NIH-CPSI,leukocyte count and ecithin corpuscles in expressed prostatic secretion(EPS),urinary flow rate,and cytokine content of TNF-α,IL-6,IL-8,were evaluated.Results The total effective rate was100.0%(60/60)in treatment group and83.3%(50/60)in the control group,and treatment group was higher than the control group(P<0.05).Pelvic pain,urinary symptom,and scrotum wet improvement time of treatment group were lower than the control group(P<0.05).Compared with before the treatment,the NIH-CPSI pain scores,urinary symptom scores,life quality score,leukocyte count and TNF-α,IL-6,IL-8content of EPS in both groups were significantly lower after treatment(P<0.05),and the cases with lecithin corpuscles+++-++++in both groups significantly increased after treatment(P<0.05).The urinary peak flow rate and mean flow rate in both groups were higher after treatment(P<0.05).There was statistical significance in the scores of NIH-CPSI pain,urinary symptom and life quality,leukocyte count and TNF-α,IL-6,IL-8content of EPS,and the cases with lecithin corpuscles++++between the two groups(P<0.05).Conclusion Dahuang Xiaozhi Suppository can improve the efficacy of treating typeⅢprostatitis infected with nano-bacteria.Combining Dahuang Xiaozhi Suppository with tetracycline can reduce prostate inflammation,with obvious efficacy.