动态磁共振成像定量参数同病理结果在诊断良恶性乳腺病变中的对比分析

Comparative Analysis of Dynamic Magnetic Resonance Imaging Quantitative Parameters and Pathological Results in the Diagnosis of Benign and Malignant Breast Lesions

目的探讨动态磁共振成像(Dynamic Enhanced MRI,DCE-MRI)定量参数同血管内皮因子(Microvessel Density,MVD)及微血管密度(Vascular Endothelial Growth Factors,VEGF)等病理结果在诊断良恶性乳腺病变中的应用。方法选取2015年3月~2016年7月行DCE-MRI扫描并于一周后取病理的患者128例为研究对象,两两比较对照组、良性组及恶性组间定量参数的差异,绘制ROC曲线分析组间差异。结果 Ktrans值及Kep值比较,良性组与恶性组及恶性组与对照组比较具有统计学意义(P<0.05)。特异性:Ktrans为88.6%,Kep为95.1%;敏感性:Ktrans为87.9%,Kep为68.7%。乳腺癌患者的Ktrans值及Kep值同MVD存在较强的相关性(r=0.597;0.612);Ktrans值及Kep值VEGF存在极强的相关性(r=0.781;0.763)。结论 DCE-MRI中定量参数同MVD、VEGF具有较强的相关性,在诊断良恶性乳腺病变中有着较好的效果。

Objective This paper aimed to investigate the application of the quantitative parameters ofdynamic enhanced MRI(DCE-MRI),microvessel density(MVD)and microvessel density(VEGF)inthe diagnosis of benign and malignant breast lesions.Methods A total of128patients who underwentDCE-MRI scans from March2015to July2016were enrolled in this study.The difference of quantitativeparameters between benign group and malignant group was analyzed.The ROC curve was used toanalyze the difference between benign and malignant group.Results There were significant statisticaldifferences between the benign group and the malignant group.The specificity of Ktrans and Kep was88.6%and95.1%,respectively;the sensitivity of Ktrans and Kep was87.9%and68.7%,respectively.There was astrong correlation with MVD(r=0.597;0.612)in the Ktrans and Kep values of breast cancer patients,therewas a strong correlation between Ktrans and Kep(r=0.781;0.763).Conclusion There is a strong correlationbetween the quantitative parameters of DCE-MRI and the pathological findings of MVD or VEGF,and ithas a good effect in the diagnosis of benign and malignant breast lesions.