益气活血通络法治疗急性心肌梗死介入术后患者43例

YiQi HuoXue TongLuo Method in Treating 43 Patients with Acute Myocardial Infarction after the Intervention

目的:观察益气活血通络法对急性心肌梗死介入术后患者中医证候积分、炎症因子和内皮功能的影响。方法:将86例患者随机分为观察组、对照组各43例,对照组采用参麦注射液和替罗非班注射液治疗,观察组在对照组的基础上给予益气活血通络方口服治疗,术后14天观察临床疗效和症状积分,测定血清白介素6(IL-6)、白介素8(IL-8)、肿瘤坏死因子α(TNF-α)炎性因子水平,彩色多普勒超声测检测肱动脉内径。结果:总有效率观察组为86.05%,对照组为65.12%,2组比较差异有统计学意义(P<0.05)。腹痛、恶心呕吐、腹胀、嗳气等症状积分,血清IL-6、IL-8、TNF-α等炎症因子,以及肱动脉内皮依赖性舒张功能(FMD)治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后组间比较,差异也有统计学意义(P<0.05)。结论:在参麦注射液、替罗非班注射液治疗的基础上采用益气活血通络法治疗急性心肌梗死介入术后患者,可提高临床疗效,降低证候积分,减轻炎症反应,增强内皮功能。

Objective:To observe the effects of YiQi HuoXue TongLuo method on TCMsyndrome integral,inflammatory factor and endothelial function of the patients with acute myocardial infarction after the intervention.Methods:Eighty-six patients were randomized into the observation group and the control group,43cases each group,the control group adopted ShenMai injection and trofiban injection,the observation group orally took YiQi HuoXue TongLuo recipe,clinical effects and TCM syndrome integral were observed in14days after the operation,the levels of IL-6,IL-8and TNF-αwere detected,internal diameter of brachial artery was detected by color Doppler ultrasound.Results:Total effective rate of the observation group was86.05%,higher than65.12%of the control group,and the difference had statistical meaning(P<0.05).The difference showed statistical meaning in the comparisons of the integrals of the syndromes such as abdominal pain,nausea and vomiting,abdominal distension,belching and others,inflammatory factors including IL-6,IL-8and TNF-α,and FMD between before and after treating within two groups(P<0.05);the difference had statistical meaning in the comparisons between both groups after treating(P<0.05).Conclusion:On the foundation of ShenMai injection and trofiban injection,YiQi HuoXue TongLuo method applied to the patients with acute myocardial infarction after the intervention could raise clinical effects,decrease syndrome integrals,alleviate the inflammation and enhance endothelial function.