补阳还五汤联合西药治疗急性脑梗死39例

BuYang HuanWu Decoction Combined with Western Medicine in Treating 39 Cases with Acute Cerebral Infarction

目的:观察补阳还五汤联合西药治疗急性脑梗死的临床疗效。方法:将78例急性脑梗死患者随机分为对照组和观察组各39例,2组均进行常规基础治疗,以前列地尔注射液10μg,加入5%葡萄糖溶液250 mL,静脉滴注,1次/d;观察组在此基础上加服补阳还五汤,1剂/d,2组治疗周期均为4周。治疗结束后对2组患者临床疗效进行评价,比较2组患者治疗前后神经功能缺损评分(NIHSS)和巴塞尔(Barthel)指数;并于治疗前后采集2组患者晨起空腹静脉血5 mL,测定血清同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)及D-二聚体水平。结果:总有效率观察组为94.87%,对照组为64.10%,2组比较差异有统计学意义(P<0.05);NIHSS评分与Barthel指数及血清Hcy、hs-CRP及D-二聚体水平治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后组间比较,差异也有统计学意义(P<0.05)。结论:中药复方补阳还五汤可减轻患者神经功能缺损程度,降低患者血清异常升高的Hcy、hs-CRP及D-二聚体水平。

Objective:To observe the clinical effects of BuYang HuanWu decoction combined with western medicine in the treatment for acute cerebral infarction.Methods:All78patients with acute cerebral infarction were randomly divided into the observation group and the control group,39cases each group,both groups received conventional treatment,prostaglandin EI,10mg dissolved in250mLof5%glucose solution,intravenous dripping,once a day,the observation group took BuYang HuanWu decoction simultaneously,one dose a day,two groups were treated for four weeks.Clinical effects of both groups were assessed by the end of the treatment,nerve function defect score(NIHSS)and the Barthel index in two groups were compared before and after the treatment.Fasting venous blood was collected before and after the treating,and the levels of homocystein(Hcy),allergic C-reactive protein(hs-CRP)and D-Dimer in the serum were determined.Results:Total effective rate of the observation group was94.87%,higher than64.10%of the control group,and there was statistical difference between two groups(P<0.05);the difference had statistical meaning in the comparisons of the levels of NIHSS scales,Barthel index and the levels of Hcy,hs-CRP and D-dimer between before and after treating(P<0.05);and the difference had statistical meaning in the comparisons between both groups after treating(P<0.05).Conclusion:BuYang HuanWu decoction could relieve nerve function defect degree of the patients,decrease the levels of Hcy,hs-CRP and D-dimer.