肝素治疗儿童重症肺炎的疗效及对血小板参数和D－二聚体的影响

Curative Effect of Heparin in the Treatment of Children with Severe Pneumonia and Its Influence on Platelet Parameters and D-Dimer

目的探讨肝素治疗儿童重症肺炎的疗效及对血小板数参数和D-二聚体(D-二聚体)的影响。方法将217例重症肺炎患儿随机分为治疗组109例和对照组108例。2组患儿均给予常规治疗，治疗组在此基础上加用小剂量肝素治疗。于治疗前及治疗后检测2组患儿血小板参数及D-二聚体浓度。结果治疗组的总有效率为93.5%，显著高于对照的75.9%(P<0.01)。经过不同方式的治疗，治疗组患儿血小板参数得到显著改善，其与对照组血小板参数的差异有统计学意义(P<0.01)；治疗组D-二聚体升高者占19.2%，显著低于对照组的50.9%(P<0.01)。结论肝素治疗儿童重症肺炎疗效显著，能明显改善患儿的高凝状态。

Objective To investigate the effect of heparin on children with severe pneumonia and the effect of platelet count and D-dimer(D-dimer).Methods217children with severe pneumonia were randomly divided into treatment group(n=109)and control group(n=108).Two groups of children were given conventional treatment,the treatment group on the basis of this plus a small dose of heparin treatment.Serum platelet parameters and D-dimer concentration were measured before and after treatment.Results The total effective rate was935%in the treatment group,which was significantly higher than that in the control group(75.9%,P<0.01).The platelet parameters of the treatment group were significantly improved after treatment in different ways,and there was significant difference between the control group and the control group(P<0.01),the statistical significance was significant;the D-dimer in the treatment group increased19.2%Which was significantly lower than that of the control group(50.9%,P<0.01).Conclusion Heparin treatment of severe pneumonia in children with significant effect,can significantly improve the hypercoagulable state of children.