儿童EB病毒感染伴面瘫1例报告并文献复习

EB virus infection with facial paralysis in children:a case report and literature review

目的探讨EB病毒感染伴面瘫患儿的治疗。方法回顾分析1例临床和实验室确诊EB病毒感染伴面瘫患儿的临床资料,并复习相关文献。结果患儿,男,2岁,因发热伴口角歪斜4天入院。入院后血清学及聚合酶链反应法确诊存在EB病毒感染及病毒血症,予阿昔洛韦治疗。患儿面瘫症状在14天后完全消失,EB病毒血症消失,短期随访未有复发。文献分析显示,对存在病毒血症的EB病毒急性感染伴面瘫患儿予阿昔洛韦抗病毒治疗证据仍有限。结论面瘫伴EB病毒血症,抗病毒治疗可能有益。

Objective To explore the treatment of children with EB virus infection accompanied by facial paralysis.Method The clinical data of a child with EB virus infection accompanied by facial paralysis was analyzed retrospectively,and the related literature were reviewed.Results A2-year-old boy was admitted to hospital due to fever and mouth askew for4days.After admission,he was confirmed to have EB virus infection and viremia by serology and polymerase chain reaction,and then treated with acyclovir.The symptoms of facial paralysis and EB viremia disappeared completely14days after antiviral treatment.There was no recurrence in the short-term follow-up.Interestingly,the literature analysis shows that there is still limited evidence for the antiviral treatment by acyclovir in children with acute infection of EB virus associated with facial paralysis.Conclusion Antiviral treatment may be beneficial to EB viremia with facial paralysis.