不同药物治疗幽门螺杆菌的临床疗效观察

Clinical efficacy of different drugs in the treatment of Helicobacter pylori

目的观察和比较2种三联疗法治疗幽门螺杆菌(Helicobacter pylori,H.pylori)的疗效。方法选择快速尿素酶及14C-尿素呼气试验确诊的150例幽门螺杆菌感染患者,随机分成对照组和实验组,各75例。其中对照组采用奥美拉唑+阿莫西林+甲硝唑,疗程10 d;实验组采用奥美拉唑+克拉霉素+阿莫西林治疗,疗程10 d,比较两组患者治疗效果。结果对照组的幽门螺杆菌根除率为90.67%,愈合率为92.00%,实验组的根除率为74.67%,愈合率为80.00%,两组幽门螺杆菌根除率及愈合率的差异有统计学意义(P<0.05)。结论奥美拉唑+克拉霉素+阿莫西林三联疗法的幽门螺杆菌根治率更高,溃疡愈合情况更好。

Objective To observe and compare the efficacy of two triple therapies in the treatment of Helicobacter pylori(H.pylori).Methods Rapid urease and14C-urea breath test confirmed150cases of patients with Helicobacter pylori infection were randomly divided into control group and experimental group,each groups of75cases.The control group with omeprazole+amoxicillin+metronidazole treatment10d;the experimental group,using omeprazole+clarithromycin+amoxicillin treatment,treatment of10d,comparison of the two groups of patients with treatment.Results Helicobacter pylori eradication rate was90.67%in the control group,the cure rate was92.00%,the experimental group the eradication rate was74.67%,the cure rate was80.00%,two groups of Helicobacter pylori eradication rate and healing rate differences are statistically significant.Conclusion Omeprazole+clarithromycin+amoxicillin triple therapy eradication rate higher better ulcer healing.