CHF患者血CA125水平与NT-proBNP及LVEF变化关系的分析

Analysis on relationship between serum CA125 level and NT-proBNP and LVEF of CHF patients

目的研究慢性心力衰竭(CHF)患者血清CA125、氨基末端脑钠肽前体(NT-pro BNP)水平与左室射血分数(LVEF)的关系及临床意义。方法选取2015年10月~2017年2月在我院接受治疗的CHF患者120例,按照NYHA分级将患者分为A组(NYHAⅡ级组)、B组(NYHAⅢ级组)和C组(NYHAⅣ级组)。另选取我院体检中心30例健康体检者作为健康对照组,检测每一位研究对象的NT-pro BNP、CA125与LVEF,对比分析各组患者NT-pro BNP、CA125与LVEF之间的相关性。结果 (1)CHF患者的CA125和NT-pro BNP均显著高于对照组,LVEF显著低于对照组(P<0.05),且CA125和NT-pro BNP随NYHA分级升高而升高,而LVEF随NYHA分级升高而降低(P<0.05)。(2)CHF患者CA125水平与NT-pro BNP呈显著正相关,与LVEF呈显著负相关(P<0.05);NT-pro BNP与LVEF呈显著负相关(P<0.05)。结论 CHF患者血清CA125与NT-pro BNP和LVEF有显著相关性,可联合检测用于判断CHF疾病发生、发展、治疗和预后。

Objective To study the relationship between serum CA125and N-terminal pro-brain natriuretic peptide(NT-proBNP)level and left ventricular ejection fraction(LVEF)of patients with chronic heart failure(CHF)and its clinical significance.Methods120patients with CHF who were treated in our hospital from October2015to February2017were selected.According to grouping standard of NYHA,patients were divided into group A(NYHAII group),group B(NYHAIII group)and group C(NYHAIV group).30healthy examined people in physical examination center were selected as the healthy control group.NT-proBNP,CA125and LVEF of every research object were detected.Correlation of NT-proBNP,CA125and LVEF of patients in all groups were compared and analyzed.Results(1)CA125and NT-proBNP of patients with CHF were significantly higher than those of control group while LVEF was significantly lower than that of the control group(P<0.05).CA125and NT-proBNP increased with increasing NYHA grading while LVEF reduced with increasing NYHA grading(P<0.05).(2)CA125level of patients with CHF was significantly positively related to NT-proBNP while it was negatively related to LVEF(P<0.05).NT-proBNP was significantly negatively related to LVEF(P<0.05).Conclusion Serum CA125of patients with CHF is significantly related to NT-proBNP and LVEF.Combination detection can be used to determine occurrence,development,treatment and prognosis of CHF.