高敏C反应蛋白和血清胱抑素C对糖尿病肾病的临床诊断价值

Clinical value of high sensitivity C reactive protein and serum cystatin C in the diagnosis of diabetic nephropathy

目的分析高敏C反应蛋白(high sensitivity C reactive protein,hs-CRP)和血清胱抑素C(cystatin C,Cys C)对糖尿病肾病的临床诊断价值。方法选取2013年6月至2016年11月本院收治的2型糖尿病伴糖尿病肾病患者72例纳入糖尿病肾病组,单纯2型糖尿病患者70例纳入单纯糖尿病组;另选取同期本院体检健康者72例纳入对照组。检测分析三组研究对象血清hs-CRP和Cys C水平。结果糖尿病肾病组患者hs-CRP和Cys C水平均显著高于单纯糖尿病组和对照组(P<0.05);单纯糖尿病组患者hs-CRP和Cys C水平均显著高于对照组(P<0.05);正常白蛋白尿组患者血清hs-CRP和Cys C水平均显著低于大量白蛋白尿组(P<0.05)。糖尿病肾病组患者血清hs-CRP和Cys C阳性率均显著高于单纯糖尿病组和对照组(P<0.05);单纯糖尿病组患者血清hs-CRP和Cys C阳性率均显著高于对照组(P<0.05)。联合检测诊断糖尿病肾病的灵敏度、特异度、准确率分别为95.8%%、84.7%、90.3%,灵敏度和准确率较单一指标诊断结果均显著提高(P<0.05)。结论血清hs-CRP和Cys C是糖尿病肾病的敏感指标,联合检测对糖尿病肾病具有较高的诊断价值。

Objective To analyze the clinical value of high sensitivity C reactive protein(hs-CRP)and serum cystatin C(Cys C)in diagnostic of diabetic nephropathy.Method72cases of diabetes mellitus type2patients with diabetic nephropathy from June2013to November2016in our hospital were allocated into diabetic nephropathy group,70cases of diabetes mellitus type2patients were allocated into diabetes group,and72healthy person were allocated into control group during the same period.The levels of serum hs-CRP and Cys C among the three groups were detected and analyzed.Result The levels of hs-CRP and Cys C in diabetic nephropathy group were significantly higher than that of diabetes group and control group(P<0.05);the levels of hs-CRP and Cys C in diabetes group were significantly higher than those in control group(P<0.05);the levels of hs-CRP and Cys C in normal serum albumin urinary group were significantly lower than macroalbuminuria group(P<0.05).The positive rates of serum hs-CRP and Cys C in diabetic nephropathy group were significantly higher than those of diabetes group and control group(P<0.05);the positive rates of hs-CRP and Cys C in diabetic nephropathy group were significantly higher than diabetes group and control group(P<0.05),the positive rates of hs-CRP and Cys C in diabetes group were significantly higher than control group(P<0.05).The sensitivity,specificity and accuracy of combined detection for diagnosis of diabetic nephropathy were95.8%,84.7%and90.3%,respectively.Sensitivity and accuracy were significantly higher than that of single detection(P<0.05).Conclusion Serum hs-CRP and Cys C are sensitive diagnose indicators of diabetic nephropathy,and combined detection has a higher diagnostic value for diabetic nephropathy.