前列地尔注射液联合缬沙坦氨氯地平片对慢性肾小球肾炎患者蛋白尿、肾功能及免疫功能的影响

The effects of Alprostadil injection combined with Valsartan and Amlodipine tablets on proteinuria, renal function and immune function in patients with chronic glomerulonephritis

目的探讨前列地尔注射液联合缬沙坦氨氯地平片对慢性肾小球肾炎患者蛋白尿、肾功能及免疫功能的影响。方法选取2014年12月至2016年12月本院肾内科收治的120例慢性肾小球肾炎患者为研究对象。采用随机数表法将其分为对照组与观察组,每组各60例。对照组患者予缬沙坦氨氯地平片降压,纠正电解质、酸碱平衡紊乱,低盐、优质蛋白饮食等常规基础治疗;观察组患者在对照组治疗基础上联合使用前列地尔注射液。比较两组患者治疗前后24小时尿蛋白定量、肾功能及免疫功能的差异。结果治疗前两组患者24小时尿蛋白定量比较无显著差异(P>0.05),治疗后观察组患者24小时尿蛋白定量显著低于对照组(P<0.05)。治疗前两组患者血肌酐、血尿素氮水平及肾小球滤过率比较均无显著差异(P>0.05);治疗后两组患者血肌酐和血尿素氮水平较本组治疗前均显著降低(P<0.05),肾小球滤过率较本组治疗前均显著升高(P<0.05),但两组患者血肌酐水平和肾小球滤过率比较均无显著差异(P>0.05),观察组患者血尿素氮水平显著低于对照组(P<0.05)。治疗前两组患者血清免疫球蛋白(immunoglobulin,Ig)A和IgG水平比较均无显著差异(P>0.05);治疗后两组患者血清IgA和IgG水平较治疗前均显著升高(P<0.05),且观察组患者血清IgA和IgG水平均显著高于对照组(P<0.05)。结论前列地尔注射液联合缬沙坦氨氯地平片可减少慢性肾小球肾炎患者24小时蛋白尿,改善肾功能,提高机体免疫功能。

Objective To investigate the effects of Alprostadil injection combined with Valsartan and Amlodipine tablets on proteinuria,renal function and immune function in patients with chronic glomerulonephritis.Method120patients with chronic glomerularnephritis treated in our hospital from December2014to December2016were selected as research objects,and they were divided into control group and observation group by random number table method,60cases in each group.Control group patients were treated with basic methods,including Valsartan and Amlodipine tablets,correcting disorder of electrolyte and acid-base balance,and low salt and hight quality protein diet.Observation group patients were treated with Alprostadil injection on the basis of control group.24hours urinary protein,renal function and immune function of the two groups were compared.Result Before treatment,there was no significant difference in24hours urinary protein between the two groups(P>0.05).After treatment,24hours urinary protein in observation group was significantly less than control group(P<0.05).Before treatment,serum creatinine,blood urea nitrogen and glomerular filtration rate of the two groups showed no significant differences(P>0.05);after treatment,serum creatinine and blood urea nitrogen of the two groups significantly decreased compared with before treatment(P<0.05),glomerular filtration rate significantly increased compared with before treatment(P<0.05),but no significant differences existed in serum creatinine and glomerular filtration rate between the two groups(P>0.05),blood urea nitrogen in observation group was significantly lower than that in control group(P<0.05).Before treatment,there were no significant differences in serum immunoglobulin(Ig)A and IgG levels between the two groups(P>0.05);after treatment,serum IgA and IgG levels of the two groups were significantly higher than those before treatment(P<0.05),and serum IgA and IgG levels of observation group were significantly higher than control group(P<0.05).Conclusion Alprostadil injection combined with Valsartan and Amlodipine tablets can reduce24hours urinary protein,improve renal function and immune function in patients with chronic glomerulonephritis.