两种质子泵抑制剂治疗高危型内镜成功止血后上消化道出血的比较

Clinical observation of two proton pump inhibitors on the treatment of high risk PUB patients after successful endoscopic hemostasis

目的比较两种不同质子泵抑制剂治疗高危型内镜成功止血后上消化道出血(PUB)的临床效果。方法将96例高危PUB内镜成功止血后患者随机分为两组,观察组48例,给予雷贝拉唑40 mg静滴后以4 mg/h输注,维持72 h。对照组48例,给予艾司奥美拉唑80 mg静滴后以8 mg/h输注,维持72 h。随后,两组患者分别给予口服雷贝拉唑或口服艾司奥美拉唑。观察两组临床疗效,72 h、7 d、30 d的再出血率、输血量、住院时间、手术率和不良反应事件发生率。结果两组临床效果,再出血率、输血量、住院时间、手术率和不良反应事件比较,差异均无统计学意义(P>0.05)。结论大剂量雷贝拉唑治疗高危型内镜成功止血后PUB患者安全有效,可以临床推广应用。

Objective Compare the clinical effectiveness of two different PPIs in high-risk pepticulcer bleeding(PUB)patients after successful endoscopic treatment.Methods96cases of high-risk PUB patients after successful endoscopic hematischesis were randomly divided into2groups,the observation group included48cases,given rabeprazole40mg intravenous infusion,followed by rebaprazole4mg/h infusion for72h.The control group included48cases,given esomeprazole80mg intravenous infusion,followed by esomeprazole8mg/h infusion for72h.Subsequently,two groups of patients given oral rabeprazole or oral esomeprazole.Observed the different between two groups of clinical effectiveness,rebleeding rate of72h,7d,30d,blood transfusion amount,time of hospital stay,operation rate and the incidence of adverse events.Results There were no statistically significant difference(P>0.05)of clinical effectiveness,rebleeding rate,operation rate,blood transfusion amount,time of hospital stay,operation rate and the incidence of adverse events.Conclusion High-dose rabeprazole treatments in patients with high-risk PUB after successful endoscopic treatment are safe and effective,which can be widely used for clinical.