不同剂量雷贝拉唑治疗急性非静脉曲张性上消化道出血的疗效观察

Effect observation of different dose of rabeprazole on the acute nonvariceal upper gastrointestinal bleeding treatment

目的比较不同剂量雷贝拉唑治疗急性非静脉曲张性上消化道出血的疗效及安全性。方法将64例急性非静脉曲张性上消化道出血患者按随机数字表法分成两组,其中大剂量组32例,给予雷贝拉唑40 mg静脉滴注后以4 mg/h持续泵入72 h;常规剂量组32例,给予雷贝拉唑20 mg静脉滴注,每12小时1次,连续3 d。比较两组患者的止血率、再出血率、输血量及不良反应。结果两组不良反应发生率无明显差异,但大剂量组止血率、再出血率、平均输血量均优于常规剂量组。结论大剂量雷贝拉唑治疗急性非静脉曲张性上消化道出血起效迅速,安全可靠,再出血少,适用于上消化道大量出血患者。

Objective To compare the effect and safety of different dose of rabeprazole in treatment of acute nonvariceal upper gastrointestinal bleeding(ANVUGIB).Methods64cases of ANVUGIB were randomized to receive a high-dose group(40mg intravenous infusion,followed by rebaprazole4mg/h infusion,n=32)or a standard-dose group(rebaprazole20mg intravenous infusion,q12h,n=32).To compare the two groups of hemostatic rate,hemostatic time,rebleeding rate,average amount of blood transfusion and adverse reaction.Results No difference between the two groups of adverse reaction rate,but the hemostatic rate,rebleeding rate and average amount of blood transfusion of the high-dose group were better than the standard-dose group.Conclusion The high-dose rabeprazole in treatment of ANVUGIB effect quickly,safe and reliable,less rebleeding,can be used as a new treatment for clinical recommendations,is suitable for the patients with massive hemorrhage.