支气管动脉化疗栓塞术治疗难治性、复发性非小细胞肺癌效果分析

Clinical analysis of bronchial artery chemoembolization for recurrent and intractable non-small cell lung cancer

目的:观察支气管动脉化疗栓塞术治疗难治性、复发性非小细胞肺癌的疗效及安全性。方法:选取58例经放、化疗及靶向治疗后无效或复发的非小细胞肺癌患者,进行超选择支气管动脉化疗栓塞治疗,比较手术前后血清肿瘤标志物[神经元特异性烯醇酶(NSE)、癌胚抗原(CEA)、细胞角蛋白19片段(CY21-1)]含量变化,观察疗效及12个月的生存率。结果:治疗后,血清肿瘤标志物NSE、CEA、CY21-1明显降低(P<0.05);肿瘤治疗有效率为77.59%(45/58),12个月生存率为79.31%(46/58)。不良反应主要为发热、胸闷胸痛等,未出现脊髓损伤等严重并发症。结论:支气管动脉化疗栓塞术治疗难治性、复发性非小细胞肺癌安全、有效,可作为难治性、复发性非小细胞肺癌临床治疗的一项较好选择。

Objective:To evaluate the safety and efficacy of bronchial artery chemoembolization in the treatment of patients with recurrent and intractable non-small cell lung cancer(NSCLC).Methods:58patients with uncontrolled NSCLC after radiotherapy and(or)chemotherapy and(or)targeted therapy were re-treated with Bronchial Artery Chemoembolization,and their serum tumor markers of NSE,CEA,CY21-1were tested before and after the re-treatment.These patients were then put on a follow-up study to have their one year survival and their responding to the re-treatment observed and recorded during the follow-up.Results:After the re-treatment,a significant decline of the serum tumor markers was observed(P<0.05).The therapeutic effect and one year survival were77.59%(45/58)and79.31%(46/58),respectively.Conclusions:Bronchial Artery Chemoembolization is a safe and effective method in treating recurrent and intractable non-small cell lung cancer patients,and can be used as a reliable and viable option for this patient population.