噻托溴铵联合沙丁胺醇治疗哮喘的临床疗效观察

Clinical observation of tiotropium bromide combined with salbutamol in the treatment of asthma

目的探讨分析噻托溴铵、沙丁胺醇联合应用治疗哮喘病症的临床效果。方法选取2012年5月~2015年4月在本院住院治疗的哮喘患者96例,随机分为甲、乙、丙三组各32例,甲组给予噻托溴铵,乙组给予沙丁胺醇,丙组联合应用噻托溴铵和沙丁胺醇,评估三组治疗效果。结果治疗后,三组患者肺功能均有所改善,各组治疗前后比较差异有统计学意义(P<0.05)。总有效率甲组为78.12%,乙组为75.00%,丙组为96.88%;总有效率丙组显著高于甲、乙组,与甲、乙组比较差异均具统计学意义(P<0.05);甲组与乙组总有效率比较差异无统计学意义(P>0.05)。治疗后三组患者FEV1、FEV1/FVC、PEF均有改善,各组治疗前后比较差异有统计学意义(P<0.05)。三指标丙组显著高于甲、乙组,与甲、乙组比较差异均具统计学意义(P<0.05);甲组与乙组三指标比较差异无统计学意义(P>0.05)。结论噻托溴铵与沙丁胺醇联合应用治疗哮喘疗效优于两者单独用药,值得临床推广。

Objective To explore the clinical effect of tiotropium bromide combined with salbutamol in thetreatment of asthma.Methods96cases of asthma treated in our hospital from May2012to April2015were selectedand randomly divided into group A,group B and group C with32cases in each.Patients in group A were treatedwith tiotropium bromide,patients in group B were treated with salbutamol,and patients in group C were treated withtiotropium bromide combined with salbutamol.Curative effects of the three groups were evaluated.Results Aftertreatment,the pulmonary function of the three groups were improved,there was significant difference between thegroups before and after treatment(P<0.05).The total effective rate of group A was78.12%,the group B was75%,andthe group C96.88%.The total effective rate of group C was significantly higher than that of group B and group C,andthe difference was statistically significant(P<0.05).The total efficiency comparison of group A and group B showedno significant difference(P>0.05).After treatment,the FEV1,FEV1/FVC,PEF of the three groups were improved,therewas significant difference between the groups before and after treatment(P<0.05).The three indexes of group Cwere significantly higher than those of group A and group B,and the differences of group C and group A,group B werestatistically significant(P<0.05).There were no statistical significances in group A and group B on the three indexdifference(P>0.05).Conclusion Curative effect of tiotropium bromide combined with salbutamol in the treatmentof asthma is better than the two drugs alone.It is worthy of promotion.