肾脏透析患者凝血和纤溶功能改变的临床观察

Clinical observation of coagulation and fibrinolysis in patients with renal dialysis

目的探讨肾脏透析患者凝血和纤溶功能改变的临床意义。方法选取60例在我院就诊的慢性肾衰竭并行维持性血液透析治疗的患者进行研究,并在不同时间点对患者进行凝血及纤溶功能检测。结果与血液透析前1h比较,血液透析开始后血小板计数明显降低(P<0.05),凝血酶原时间、活化部分凝血活酶时间均明显延长(P<0.05);且与血液透析时比较,透析后D-二聚体、组织纤溶酶原活物均明显升高(P<0.05)。结论肾脏透析可对患者凝血及纤溶功能产生显著影响,可在一定程度上促进患者凝血途径启动,并促进继发性纤溶功能运行。

Objective To clinical significance of of coagulation and fibrinolysis in renal dialysis patients.Methods60patients in our hospital with chronic renal failure concurrent maintenance hemodialysis treatment were studied,andthe patients at different time points of blood coagulation and fibrinolytic function were tested.Results Comparedwith1H blood before dialysis,hemodialysis began after the platelet count decreased significantly(P<0.05),theprothrombin time,activated partial thromboplastin time were significantly prolonged(P<0.05).And compared withdialysis,dialysis after two D-dimer,tissue plasminogen increased significantly(P<0.05).Conclusion Renal dialysiscan significantly affect coagulation and fibrinolysis function.It can promote patients to start coagulation pathway to acertain extent,and promote the secondary fibrinolysis function.