布地奈德联合孟鲁司特治疗小儿咳嗽变异性哮喘的效果

Effect of budesonide combined with montelukast in the treatment of children with cough variant asthma

目的探讨布地奈德联合孟鲁司特治疗小儿咳嗽变异性哮喘的效果。方法选取我院2014年4月~2015年9月收治的108例小儿咳嗽变异性哮喘患者,采用随机分配的方式,分为观察组和对照组各54例,对照组患者给予雾化吸入布地奈德治疗,观察组患者给予布地奈德联合孟鲁司特治疗,对比两组患者的临床效果。结果两组患者治疗后血清Ig E、白细胞介素-4、肿瘤坏死因子-α下降明显(P<0.05),观察组患者下降水平明显低于对照组(P<0.05),均具有统计学意义;观察组患者症状的缓解与消失时间也远远低于对照组(P<0.05),具有统计学意义;治疗后1年随访,观察组患者复发率为3.70%,对照组患者复发率为11.11%,两组有显著差异(P<0.05),具有统计学意义。结论布地奈德联合孟鲁司特治疗小儿咳嗽变异性哮喘有着较好的临床效果,不良反应较少,安全性较高,值得在临床推广应用。

Objective To investigate the effect of budesonide combined with montelukast in the treatment ofchildren with cough variant asthma.Methods108cases of children with cough variant asthma in our hospital fromApril2014to September2016were selected and divided into observation group and control group with54casesin each group,by random allocation method.Patients in control group were treated with budesonide inhalationtherapy,and patients in observation group were given budesonide combined with montelukast treatment.The clinicaleffects were compared between the two groups.Results After treatment,The serum IgE,interleukin-4,tumornecrosis factor-αof the two groups were decreased significantly(P<0.05).The decrease range of the observationgroup was lower than that of the control group(P<0.05).And there was statistical significance.The remission anddisappearance time of the patients in the observation group was much lower than that in the control group(P<0.05).And there was statistical significance.After1years of treatment,the recurrence rate was3.70%in the observation group,and it was11.11%in the control group,and there was a significant difference between the two groups(P<0.05),whichwas statistically significant.Conclusion Budesonide combined with montelukast in the treatment of children with coughvariant asthma has good clinical effect.It has less adverse reaction,and high safety.It is worthy of clinical application