多种药物联合治疗对艾滋病合并隐球菌脑膜炎患者临床症状及治疗效果的影响

Influence of combined treatment of multiple drugs on the clinical symptoms and effect of AIDS patients with cryptococcal meningitis

目的:探讨氟康唑、伏立康唑联合伊曲康唑治疗艾滋病合并隐球菌脑膜炎患者的临床效果及价值。方法:收治艾滋病合并隐球菌脑膜炎患者40例,随机平分两组。观察组给予氟康唑、伏立康唑联合伊曲康唑治疗,对照组给予两性毒素B联合氟康唑治疗,比较两组的临床症状、隐球菌转阴率及病死率。结果:观察组隐球菌转阴率80.0%,明显高于对照组的60.0%;观察组病死率5.0%,明显低于对照组的15.0%,差异有统计学意义(P<0.05);观察组意识障碍、恶心呕吐、头痛及抽搐症状明显轻于对照组,差异具有统计学意义(P<0.05)。结论:在艾滋病合并隐球菌脑膜炎的临床治疗上,氟康唑、伏立康唑联合伊曲康唑治疗可改善患者临床症状,减少患者死亡。

Objective:To explore the value and clinical effect of fluconazole,voriconazole and itraconazole in the treatment ofAIDS patients with cryptococcal meningitis.Methods:40cases of cryptococcal meningitis in AIDS patients were selected.Theywere randomly divided into the two groups on average.The observation group was treated with fluconazole,voriconazole anditraconazole.The control group was treated with amphotericin B combined with fluconazole.The clinical symptoms,the rate ofnegative cocci and the mortality of cryptococcus neoformans were compared between groups.Results:The cryptococcal negativerate of the observation group of80%was significantly higher than the control group of60%.The mortality of the observation groupof5%was significantly lower than that of15%in the control group,with significant difference(P<0.05).The consciousnessdisorder,nausea and vomiting,headache and seizure symptoms in the observation group were significantly lighter than the controlgroup,the difference was statistically significant(P<0.05).Conclusion:During the clinical treatment of cryptococcal meningitis inAIDS,fluconazole,voriconazole and itraconazole therapy can improve clinical symptoms,reduce the patient's death.