单唾液酸四己糖神经节苷脂钠注射液对糖尿病周围神经病变的临床疗效观察

Clinical observation on the effect of single sialic acid four hexose ganglioside injection in the treatment of diabetic peripheral neuropathy

目的:探究单唾液酸四己糖神经节苷脂钠注射液(GM1)在糖尿病神经病变(DPN)临床治疗中的疗效观察。方法:将64例DPN患者随机分为使用GM1的治疗组和甲钴铵注射液的对照组,疗程均3个月。对治疗前后四肢主要运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)的变化进行检测,比较治疗前后患者血清一氧化氮(NO)水平,并观察临床症状改善情况。结果:治疗组在MNCV和SNCV、血清NO水平、临床症状改善方面均优于对照组。结论:GM1可使DPN患者的临床症状和神经传导速度获得有效改善。

Objective:To investigate the efficacy of single sialic acid four hexose ganglioside sodium injection(GM1)in the clinicaltreatment of diabetic neuropathy(DPN).Methods:64cases of DPN patients were randomly divided into the GM1treatment groupand the mecobalamin control group,the course of treatment was3months.The changes of the main motor nerve conductionvelocity(MNCV)and sensory nerve conduction velocity(SNCV)were measured before and after treatment,and the serum nitricoxide(NO)levels were compared between the two groups before and after treatment,we observed the improvement of clinicalsymptoms.Results:The treatment group was superior to the control group in motor nerve and sensory nerve conduction velocity,serum nitric oxide levels,and improvement of clinical symptoms.Conclusion:The single sialic acid four hexose ganglioside sodiuminjection(GM1)can effectively improve the clinical symptoms and nerve conduction velocity in patients with DPN.