老年心肌梗死患者外周血内NT-proBNP水平与梗死部位和预后质量的相关性分析

Study on the correlation between NT-proBNP levels in peripheral blood on infarct site and prognosis in elderly patients with myocardial infarction

目的:分析、探讨老年心肌梗死患者外周血NT-proBNP(N末端B型利钠肽原)水平与梗死部位及预后质量的相关性。方法:收治老年心肌梗死患者80例,根据梗死部位分为前壁心梗组(n=38)和下壁心梗组(n=42),检测患者外周血内NT-proBNP,记录早期心血管事件。结果:前壁心梗组的NT-proBNP1和NT-proBNP2水平均显著高于下壁心梗组,差异有统计学意义(P<0.05);血浆NT-proBNP浓度与心血管事件有关,发生心血管事件的NT-proBNP1和NT-proBNP2水平均显著高于未发生心血管事件的患者,心力衰竭和死亡的发生组与未发生组NT-proBNP1和NT-proBNP2水平比较,差异有统计学意义(P<0.05)。结论:老年心肌梗死患者外周血内NT-proBNP水平与患者梗死部位有关,前壁心梗组的NT-proBNP水平明显高于下壁心梗组,且NT-proBNP浓度是老年心肌梗死患者早期心血管事件的预测因子。

Objective:To investigate the correlation between the level of NT-proBNP(N terminal B type natriuretic peptide)and itseffect on infarct site and prognosis in elderly patients with myocardial infarction.Methods:80elderly patients with myocardialinfarction were divided into the anterior myocardial infarction group(n=38)and the inferior wall infarction group(n=42)according tothe location of the infarction.The NT-proBNP in peripheral blood of the patients was detected and the early cardiovascular eventswere recorded.Results:The NT-proBNP1and NT-proBNP2in the anterior myocardial infarction group were significantly higherthan those in the inferior myocardial infarction group,and the difference was statistically significant(P<0.05).The plasmaNT-proBNP concentration was associated with cardiovascular events;the NT-proBNP1and NT-proBNP2levels of patients withthe occurrence of cardiovascular events were significantly higher than those without the occurrence of cardiovascular events;theNT-proBNP1and NT-proBNP2levels in patients with heart failure and death compared to those who did not dead;the differenceswere statistically significant(P<0.05).Conclusion:The level of NT-proBNP in peripheral blood of elderly patients with myocardialinfarction is related to the location of infarction.The level of NT-proBNP in the anterior myocardial infarction group issignificantly higher than that in the inferior myocardial infarction group.The concentration of NT-proBNP is a predictor ofcardiovascular events in elderly patients with early myocardial infarction.