成人特发性膜性肾病79例临床病理分析

Clinical and Pathological Analysis of 79 Cases of Adult Idiopathic Membranous Nephropathy

目的分析并研究膜性肾病的临床表现、病理特点,并探究相关的治疗预后。方法对所有患者的临床资料进行回顾性分析,对患者的发病年龄、患者的发病原因和患者的临床表现以及实验室的检查、肾病病理特征、治疗和预后等相关情况进行总结。结果膜性肾病在成人原发肾病综合征中并不罕见,膜性肾病患者通常没有前驱感染,大多表现为肾病综合征,这种疾病特点是病程进展缓慢,而且相对较长。结论不同年龄段特发性膜性肾病患者临床特点与病理特征有相似之处,也有一定差异。老年患者血压较高、合并症多、肾小管受损发生率高,需控制好血压、避免肾小管进一步受损。青年患者临床表现多样,如无穿刺禁忌,尽可能行肾穿刺明确诊断,进而采取针对性治疗。

Objective To analyze and study the clinical and pathological features of membranous nephropathy,and to explore the related treatment prognosis.Methods The clinical data of all patients were retrospectively analyzed,causes and pathogenesis of patients,age of onset,the clinical manifestations,laboratory examination,renal pathological features,treatment and prognosis were summarized.Results The membranous nephropathy was not rare in patients with membranous nephropathy syndrome.In patients with membranous nephropathy,there was usually no pre infection,most of them were nephrotic syndrome.The disease was characterized by slow progression and relatively long course of disease.Conclusion The clinical features and pathological features of idiopathic membranous nephropathy in different age groups are similar,but there are some differences.The elderly patients have higher blood pressure,more complications and higher incidence of renal tubular damage,so they need to control their blood pressure and avoid further damage to the renal tubules.The clinical manifestations of young patients are diverse,such as no contraindications to puncture,renal biopsy as possible as possible,and then take targeted treatment.