丁苯酞联合脑心通胶囊对脑梗死患者侧支循环血流速度及神经功能的影响

The effects of butylphthalide plus the Naoxintong capsule on collateral circulation blood flow velocity and neurological function in patients with cerebral infarction

目的:探讨丁苯酞联合脑心通胶囊对脑梗死患者侧支循环血流速度及神经功能的影响。方法:选择2015年3月-2016年9月在我院治疗的132例脑梗死患者作为研究对象,随机分为观察组66例与对照组66例。对照组采用丁苯酞治疗,观察组采用丁苯酞联合脑心通胶囊治疗。治疗1个月后,比较两组侧支循环血流速度及神经功能缺损情况。结果:治疗前两组NIHSS评分相比,差异无统计学意义(P>0.05);治疗后两组NIHSS评分均降低,且观察组低于对照组,差异有统计学意义(P<0.05;治疗前两组各动脉血流速度相比,差异无统计学意义(P>0.05);治疗后与对照组相比,观察组MCA血流速度较快,ACA、PCA血流速度较慢,差异有统计学意义(P<0.05)。结论:脑梗死患者采用丁苯酞联合脑心通胶囊治疗效果显著,可明显改善患者神经功能及侧支循环血流速度,值得临床广泛应用。

Objective:To investigate the effects of butylphthalide plus the Naoxintong capsule on collateral circulation blood flow velocity and neurological function in patients with cerebral infarction.Methods:132patients were randomly divided into the observationgroup(n=66)and the control group(n=66).The control group was treated with butylphthalide;and the observation group was treated withbutylphthalide plus the Naoxintong capsule.After1month of treatment,the blood flow velocity and neurological deficit were comparedbetween groups.Results:The difference in scores of NIHSS between groups before treatment was no statistical significance(P>0.05);aftertreatment,the scores of NIHSS in groups were decreased;the score of NIHSS in the observation group were lower than that in the controlgroup,with a statistically significant difference(P<0.05).After treatment,compared with the control group,the blood flow velocity ofACA and PCA in the observation group was faster(P<0.05).Conclusion:The butylphthalide plus the Naoxintong capsule can improve theneurological function and blood flow velocity of collateral circulation,is worthy of clinical application.