广东地区克罗恩病的中医证型分布特征研究

Distribution characteristics of TCM syndromes of Crohn's disease in Guangdong

目的:探讨广东地区克罗恩病的中医证型分布规律,以提高中医对克罗恩病的认识,为今后中医诊治及预防本病提供帮助和参考依据。方法:选择2008年1月-2012年12月在广东省中医院及中山市中医院门诊及住院确诊为克罗恩病的患者作为研究对象,填写统一调查问卷,分析研究广东地区克罗恩病的中医证型分布规律。结果:共收集符合研究标准的中医病例60例,其中广东省中医院39例,中山中医院21例;活动期35例(58.33%),缓解期25例(41.67%)。证型分布以脾胃虚寒证居首,共22例(36.7%);其次为气滞血瘀证20例(33.3%);湿热蕴结证9例(15%),寒湿困脾证3例(5%)、肝郁脾虚证3例(5%),其他类型3例。各证型间例数比较差异有统计学意义(P<0.05);虚实辨证以虚实相兼证(65%)为主,寒热辨证以寒证(56.7%)为主。活动期证型以气滞血瘀(37.14%)主,缓解期证型以脾胃虚寒(44%)为主,活动期与缓解期主要证型之间比较,差异具有统计学意义(P<0.05)。结论:广东地区克罗恩病的中医证型以脾胃虚寒证、气滞血瘀证为主,活动期以气滞血瘀主,缓解期以脾胃虚寒为主,可为中医对该病的诊治及预防提供参考依据。

Objective:To investigate the distribution pattern of TCM syndromes of Crohn’s disease in Guangdong area,so as toimprove the TCM understanding of Crohn’s disease,and provide the assistance and reference for the treatment and prevention of Crohn’sdisease in the future.Methods:Patients with Crohn’s disease treated in Guangdong Province Traditional Chinese Medical Hospital andZhongshan Hospital of Traditional Chinese Medicine from January2008to December2012year were selected as the research subjects,they were asked to fill in the unified questionnaire to analyze and study the distribution characteristics of TCM syndromes of Crohn’sdisease in Guangdong.Results:A total of60cases were collected,among whom39cases were in Guangdong Province Traditional ChineseMedical Hospital and21cases were in Zhongshan Hospital of Traditional Chinese Medicine;35cases were in the active phase(58.33%)and25cases were in relief phase(41.67%).The major syndrome was spleen deficiency syndrome of22cases(36.7%),which was followedby20cases of Qi stagnation and blood stasis syndrome(33.3%),9cases of damp heat syndrome(15%),3cases of cold dampness spleensyndrome(5%)and3cases of others syndrome.The difference of syndromes showed statistical significance(P<0.05);Syndrome ofdeficiency and excess simultaneously was the major syndrome(65%)in deficiency and excess differentiation,cold syndrome was themajor syndrome in cold and warm differentiation(56.7%).Qi stagnation and blood stasis syndrome was the major syndrome(37.14%)inthe active phase and spleen deficiency syndrome was the major syndrome(44%)in the relief phase,the difference of different phases wasof statistical significance(P<0.05).Conclusion:The major TCM syndromes of Crohn’s disease in Guangdong area were spleen deficiencysyndrome and Qi stagnation and blood stasis syndrome.Qi stagnation and blood stasis syndrome was the major syndrome in the activephase and spleen deficiency syndrome was the major syndrome in the relief phase,which could provide reference for the TCM diagnosisand treatment for the disease.