定坤丸对子宫内膜发育不良所致不孕症患者妊娠率的影响

Effects of Dingkun Wan on pregnancy rate in infertile patients with endometrial dysplasia

目的:探讨分析定坤丸治疗子宫内膜发育不良性不孕症的临床疗效,并分析对妊娠率的影响。方法:2013年10月-2015年12月收治于我院的不孕症患者60例为观察组,其合并子宫内膜发育不良,并采用戊酸雌二醇片联合定坤丸治疗。同期入院患者70例为对照组,均采用阿司匹林联合戊酸雌二醇片治疗。阴道超声检测患者用药前后排卵日子宫内膜厚度,并采用放射免疫法检测排卵后1周孕酮水平。随访6~12个月,统计患者妊娠率。结果:对照组患者用药前子宫内膜厚度为(6.80±0.54)mm,用药后为(6.89±0.61)mm;而观察组用药前后上述指标分别为(6.81±0.57)mm、(7.73±0.68)mm。比较显示,两组患者用药前子宫内膜厚度无显著差异(P>0.05),而观察组患者用药后子宫内膜厚度优于对照组(P<0.05)。观察组患者排卵后1周孕酮水平以及妊娠率均优于对照组(P<0.05)。结论:对于子宫内膜发育不良性不孕症,定坤丸可有效改善子宫内膜厚度,提高孕酮水平,进而增加妊娠成功率。

Objective:To investigate clinical efficacy of the Dingkun Wan on endometriosis dysplasia and analyze the effect onpregnancy rate.Methods:60cases were treated with estradiol valerate and Dingkun Wan.70patients as the control group,were treatedwith aspirin with estradiol valerate tablets.Results:The thickness of the endometrium was(6.80±0.54)mm in the control group and(6.89±0.61)mm after treatment.The above indexes were(6.81±0.57)mm,(7.73±0.68)mm.There was no significant difference inendometrial thickness between two groups(P>0.05),while the endometrial thickness in the observation group was better than the controlgroup(P<0.05).The levels of progesterone and the pregnancy rate were significantly better in the observation group(P<0.05).Conclusion:For endometrial dysplasia infertility,Dingkun Wan can effectively improve the thickness of the endometrium,increase progesterone levels,thereby increasing the success rate of pregnancy.