氟喹诺酮类药物所致急性间质性肾炎临床特点及治疗研究

Clinical characteristics and treatment of acute interstitial nephritis caused by fluoroquinolones

目的:探究氟喹诺酮类药物所致急性间质性肾炎的临床特点和治疗方法。方法:选择2014年5月-2015年5月我院内的氟喹诺酮类药物所致急性间质性肾炎患者31例为观察组,健康体检者31例为对照组。分别对两组进行血常规、尿常规和肾功能检查与比较。并对观察组患者给予停用氟喹诺酮类药物,应用糖皮质激素进行治疗,对治疗结果进行评价。结果:血常规检查后,观察组患者的C反应蛋白、红细胞沉降率、免疫球蛋白G、血清肌酐水平和血清胱抑素C水平明显高于对照组,差异有统计学意义(P<0.05)。尿常规检查后,观察组患者的尿蛋白、微球蛋白、重碳酸盐、白细胞、NAG酶和红细胞的水平高于对照组,差异有统计学意义(P<0.05)。治疗后观察组有28例患者治愈,治愈率为90.3%。结论:氟喹诺酮类药物治疗急性间质性肾炎的临床特点为非特异性的,临床中患者在应用氟喹诺酮类药物时需要定期的检查,同时停用氟喹诺酮类药物和糖皮质激素治疗,可以得到较好的治疗效果。

Objective:To investigate clinical characteristics and treatment of acute interstitial nephritis caused by fluoroquinolones.Methods:31patients were selected as the observation group and31healthy subjects as control group.Results:The levels of C-reactiveprotein,erythrocyte sedimentation rate,immunoglobulin G,serum creatinine and serum cystatin C were significantly higher in theobservation group than the control group(P<0.05).After urine routine examination,the levels of urinary protein,microglobulin,bicarbonate,white blood cell,NAG enzyme and erythrocyte in the observation group were higher than the control group(P<0.05).In theobservation group,28patients were cured after treatment,the cure rate was90.3%.Conclusion:Clinical characteristics of acute interstitialnephritis from fluoroquinolones are nonspecific.They should be checked regularly,and fluoroquinolones and glucocorticoids are treated.