血必净注射液的不良反应文献分析

Literature review on adverse reactions induced by xuebijing injection

目的分析血必净注射液不良反应的规律、特点和风险因素,为临床安全合理用药提供依据。方法以"血必净"、"不良反应"、"过敏"、"致"、"例"为主题词,检索中国知网、万方数据库、维普科技期刊全文数据库,并对文献资料进行提取、归纳、分析。结果共纳入24篇文献,涉及83例病人,累及系统器官主要为呼吸系统损害、皮肤损害、心血管系统损害等,不良反应以胸闷、呼吸困难、瘙痒、心悸等最为常见,严重可致过敏性休克。结论重视血必净注射液引起的不良反应,防范不良反应发生,确保用药安全。

Objective To provide the evidence of safe and rational clinical drug use,the characteristics,mechanisms and risk factors of adverse reactions induced by Xuebijing injection were analyzed.Methods Using"Xuebijing"adverse reaction"allergy"and"lead to"as key words to search and retrieve articles in the CNKI,Wanfang and VIP database.References which met the inclusion and exclusion criteria were extracted and analyzed.Results A total of24articles were included,involving83patients.Systems-organs mainly involved in adverse reactions were respiratory system,skin and cardiovascular systemic damage,etc.Chest tightness,dyspnea,pruritus and palpitations were the most common adverse reactions,even slip into anaphylactic shock.Conclusion It is important to pay attention to the adverse reactions caused by Xuebijing injection,in order to prevent adverse drug reactions and ensure the safe clinical drug use.